OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 42, Iss. 16 — Jun. 1, 2003
  • pp: 3117–3128

Three-dimensional optical tomography: resolution in small-object imaging

Hamid Dehghani, Brian W. Pogue, Jiang Shudong, Ben Brooksby, and Keith D. Paulsen  »View Author Affiliations


Applied Optics, Vol. 42, Issue 16, pp. 3117-3128 (2003)
http://dx.doi.org/10.1364/AO.42.003117


View Full Text Article

Enhanced HTML    Acrobat PDF (3267 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Near-infrared (NIR) optical tomography can provide estimates of the internal distribution of optical absorption and transport scattering from boundary measurements of light propagation within biological tissue. Although this is a truly three-dimensional (3D) imaging problem, most research to date has concentrated on two-dimensional modeling and image reconstruction. More recently, 3D imaging algorithms are demonstrating better estimation of the light propagation within the imaging region and are providing the basis of more accurate image reconstruction algorithms. As 3D methods emerge, it will become increasingly important to evaluate their resolution, contrast, and localization of optical property heterogeneity. We present a concise study of 3D reconstructed resolution of a small, low-contrast, absorbing and scattering anomaly as it is placed in different locations within a cylindrical phantom. The object is an 8-mm-diameter cylinder, which represents a typical small target that needs to be resolved in NIR mammographic imaging. The best resolution and contrast is observed when the object is located near the periphery of the imaging region (12–22 mm from the edge) and is also positioned within the multiple measurement planes, with the most accurate results seen for the scatter image when the anomaly is at 17 mm from the edge. Furthermore, the accuracy of quantitative imaging is increased to almost 100% of the target values when a priori information regarding the internal structure of imaging domain is utilized.

© 2003 Optical Society of America

OCIS Codes
(110.6880) Imaging systems : Three-dimensional image acquisition
(170.3010) Medical optics and biotechnology : Image reconstruction techniques

History
Original Manuscript: August 30, 2002
Revised Manuscript: December 3, 2002
Published: June 1, 2003

Citation
Hamid Dehghani, Brian W. Pogue, Jiang Shudong, Ben Brooksby, and Keith D. Paulsen, "Three-dimensional optical tomography: resolution in small-object imaging," Appl. Opt. 42, 3117-3128 (2003)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-42-16-3117


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. B. W. Pogue, S. Geimer, T. O. McBride, S. Jiang, U. L. Österberg, K. D. Paulsen, “Three-dimensional simulation of near-infrared diffusion in tissue: boundary condition and geometry analysis for finite element image reconstruction,” Appl. Opt. 40, 588–600 (2001). [CrossRef]
  2. H. Dehghani, B. W. Pogue, S. P. Poplack, K. D. Paulsen, “Multiwavelength three dimensional near infrared tomography of the breast: initial simulation, phantom and clinical results,” Appl. Opt.135–145 (2003). [CrossRef]
  3. T. O. McBride, B. W. Pogue, S. P. Poplack, S. Soho, W. A. Wells, S. Jiang, U. L. Osterberg, K. D. Paulsen, “Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast,” J. Biomed. Opt. 7, 72–79 (2002). [CrossRef] [PubMed]
  4. J. C. Hebden, H. Veenstra, H. Dehghani, E. M. C. Hillman, M. Schweiger, S. R. Arridge, D. T. Delpy, “Three-dimensional time-resolved optical tomography of a conical breast phantom,” Appl. Opt. 40, 3278–3287 (2001). [CrossRef]
  5. S. Fantini, M. A. Franceschini, E. Gratton, D. Hueber, W. Rosenfeld, D. Maulik, P. G. Stubblefield, M. R. Stankovic, “Non-invasive optical mapping of the piglet in real time,” Opt. Express 4, 308–314 (1999). [CrossRef] [PubMed]
  6. H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, M. Tamaru, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70, 3595–3602 (1999). [CrossRef]
  7. D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18, 57–75 (2001). [CrossRef]
  8. S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41–R93 (1999). [CrossRef]
  9. H. Jiang, K. D. Paulsen, U. L. Osterberg, M. Patterson, “Frequency domain optical image reconstruction in turbid media: an experimental study of single-target delectability,” Appl. Opt. 36, 52–63 (1997). [CrossRef] [PubMed]
  10. B. W. Pogue, C. Willscher, T. McBride, U. L. Osterberg, K. D. Paulsen, “Contrast-detail analysis for detection and characterization with near-infrared diffuse tomography,” Med. Phys. 27, 2693–2700 (2000). [CrossRef]
  11. M. Schweiger, S. R. Arridge, “Comparison of two- and three-dimensional reconstruction methods in optical tomography,” Appl. Opt. 37, 7419–7428 (1998). [CrossRef]
  12. H. Jiang, Y. Xu, N. Iftimia, J. Eggert, K. Klove, L. Baron, L. Fajardo, “Three-dimensional optical tomographic imaging of breast in a human subject,” IEEE Trans. Med. Imaging 20, 1334–1340 (2001). [CrossRef]
  13. A. Gibson, R. M. Yusof, E. M. C. Hillman, H. Dehghani, J. Riley, N. Everdale, R. Richards, J. C. Hebden, M. Schweiger, S. R. Arridge, D. T. Delpy, “Optical tomography of a realistic neonatal head phantom,” Appl. Opt. 42, 3109–3116 (2003). [CrossRef] [PubMed]
  14. B. W. Pogue, X. Song, T. D. Tosteson, T. O. McBride, S. Jiang, K. D. Paulsen, “Statistical analysis of non-linearlly reconstructed near-infrared tomographic images: Part I - theory and simulation,” IEEE Trans. Med. Imaging 21, 755–763 (2002). [CrossRef] [PubMed]
  15. X. Song, B. W. Pogue, T. D. Tosteson, T. O. McBride, S. Jiang, K. D. Paulsen, “Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part II - experimental interpretation,” IEEE Trans. Med. Imaging 21, 764–772 (2002). [CrossRef] [PubMed]
  16. T. O. McBride, “Spectroscopic reconstructed near infrared tomographic imaging for breast cancer diagnosis,” Ph.D. dissertation (Dartmouth College, Hanover, N.H., 2001).
  17. M. J. Eppstein, D. J. Hawrysz, A. Godavarty, E. M. Sevick-Muraca, “Three-dimensional, Baysian image reconstruction from sparse and noisy data sets: near-infrared fluorescence tomography,” Proc. Natl. Acad. Sci. USA 99, 9619–9624 (2002). [CrossRef]
  18. M. Schweiger, S. R. Arridge, M. Hiroaka, D. T. Delpy, “The finite element model for the propagation of light in scattering media: boundary and source conditions,” Med. Phys. 22, 1779–1792 (1995). [CrossRef] [PubMed]
  19. H. Jiang, K. D. Paulsen, U. L. Osterberg, B. W. Pogue, M. S. Patterson, “Optical image reconstruction using frequency-domain data: simulations and experiments,” J. Opt. Soc. Am. A 13, 253–266 (1996). [CrossRef]
  20. S. R. Arridge, M. Schweiger, M. Hiraoka, D. T. Delpy, “A finite element approach for modeling photon transport in tissue,” Med. Phys. 20, 299–309 (1993). [CrossRef] [PubMed]
  21. K. D. Paulsen, H. Jiang, “Spatially varying optical property reconstruction using a finite element diffusion equation approximation,” Med. Phys. 22, 691–701 (1995). [CrossRef] [PubMed]
  22. S. R. Arridge, M. Schweiger, “Photon-measurement density functions. Part 2: Finite-element-method calculations,” Appl. Opt. 34, 8026–8037 (1995). [CrossRef] [PubMed]
  23. R. Penrose, “A generalized inverse for matrices,” Proc. Cambridge Philos. Soc. 51, 406–413 (1955). [CrossRef]
  24. J. Schoberl, “NETGEN—an automatic 3D tetrahedral mesh generator,” http://www.sfb013.uni-linz.ac.at/∼joachim/netgen/ .
  25. M. Schweiger, S. R. Arridge, “Optical tomographic reconstruction in a complex head model using a priori region boundary information,” Phys. Med. Biol. 44, 2703–2722 (1999). [CrossRef] [PubMed]
  26. V. Ntziachristos, A. G. Yodh, M. Schnall, B. Chance, “Concurrent MRI and diffuse optical tomography of breast following Indocyanine Green enhancement,” Proc. Natl. Acad. Sci. USA 97, 2767–2772 (2000). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited