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Applied Optics

Applied Optics


  • Vol. 42, Iss. 16 — Jun. 1, 2003
  • pp: 3154–3162

Optode positional calibration in diffuse optical tomography

Jonathan J. Stott, Joseph P. Culver, Simon R. Arridge, and David A. Boas  »View Author Affiliations

Applied Optics, Vol. 42, Issue 16, pp. 3154-3162 (2003)

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Although diffuse optical tomography is a highly promising technique used to noninvasively image blood volume and oxygenation, the reconstructed data are sensitive to systemic differences between the forward model and the actual experimental conditions. In particular, small changes in optode location or in the optode-tissue coupling coefficient significantly degrade the quality of the reconstruction images. Accurate system calibration therefore is an essential part of any experimental protocol. We present a technique for simultaneously calibrating optode positions and reconstructing images that significantly improves image quality, as we demonstrate with simulations and phantom experiments.

© 2003 Optical Society of America

OCIS Codes
(170.5280) Medical optics and biotechnology : Photon migration
(170.6960) Medical optics and biotechnology : Tomography

Original Manuscript: October 7, 2002
Revised Manuscript: January 17, 2003
Published: June 1, 2003

Jonathan J. Stott, Joseph P. Culver, Simon R. Arridge, and David A. Boas, "Optode positional calibration in diffuse optical tomography," Appl. Opt. 42, 3154-3162 (2003)

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