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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 42, Iss. 16 — Jun. 1, 2003
  • pp: 3170–3186

Time-domain optical mammography: initial clinical results on detection and characterization of breast tumors

Dirk Grosenick, K. Thomas Moesta, Heidrun Wabnitz, Jörg Mucke, Christian Stroszczynski, Rainer Macdonald, Peter M. Schlag, and Herbert Rinneberg  »View Author Affiliations


Applied Optics, Vol. 42, Issue 16, pp. 3170-3186 (2003)
http://dx.doi.org/10.1364/AO.42.003170


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Abstract

Mammograms of 35 patients suspected of breast cancer were taken along craniocaudal and mediolateral projections with a dual-wavelength scanning laser pulse mammograph measuring time-resolved transmittance. Among 26 tumors known from routine clinical diagnostics, 17 tumors were detected retrospectively in optical mammograms. Effective tumor optical properties derived from a homogeneous model were used to deduce physiological information. All tumors exhibited increased total hemoglobin concentration and decreased or unchanged blood oxygen saturation compared with surrounding healthy tissue. Scatter plots based on a pixelwise analysis of individual mammograms were introduced and applied to represent correlations between characteristic quantities derived from measured distributions of times of flight of photons.

© 2003 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3830) Medical optics and biotechnology : Mammography
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6920) Medical optics and biotechnology : Time-resolved imaging

History
Original Manuscript: September 1, 2002
Revised Manuscript: November 6, 2002
Published: June 1, 2003

Citation
Dirk Grosenick, K. Thomas Moesta, Heidrun Wabnitz, Jörg Mucke, Christian Stroszczynski, Rainer Macdonald, Peter M. Schlag, and Herbert Rinneberg, "Time-domain optical mammography: initial clinical results on detection and characterization of breast tumors," Appl. Opt. 42, 3170-3186 (2003)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-42-16-3170

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