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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 42, Iss. 19 — Jul. 1, 2003
  • pp: 4088–4094

Transmission- and side-detection configurations in ultrasound-modulated optical tomography of thick biological tissues

Jun Li, Sava Sakadžić, Geng Ku, and Lihong V. Wang  »View Author Affiliations


Applied Optics, Vol. 42, Issue 19, pp. 4088-4094 (2003)
http://dx.doi.org/10.1364/AO.42.004088


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Abstract

Ultrasound-modulated optical tomography of thick biological tissues was studied based on speckle-contrast detection. Speckle decorrelation was investigated with biological tissue samples of various thicknesses. Images of optically absorbing objects buried in biological tissue samples with thicknesses up to 50 mm were obtained in a transmission-detection configuration. The image contrast was more than 30%, and the spatial resolution was approximately 2 mm. In addition, a side-detection scheme along with two specific configurations were examined, and the advantages were demonstrated. Experimental results implied feasibility of applying the ultrasound-modulation technique to characterize optical properties in inhomogeneous biological tissues.

© 2003 Optical Society of America

OCIS Codes
(110.7050) Imaging systems : Turbid media
(110.7170) Imaging systems : Ultrasound
(120.6150) Instrumentation, measurement, and metrology : Speckle imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging

History
Original Manuscript: October 31, 2002
Revised Manuscript: March 11, 2003
Published: July 1, 2003

Citation
Jun Li, Sava Sakadžić, Geng Ku, and Lihong V. Wang, "Transmission- and side-detection configurations in ultrasound-modulated optical tomography of thick biological tissues," Appl. Opt. 42, 4088-4094 (2003)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-42-19-4088


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