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Applied Optics

Applied Optics


  • Vol. 42, Iss. 19 — Jul. 1, 2003
  • pp: 4095–4101

Single-scattering spectroscopy for the endoscopic analysis of particle size in superficial layers of turbid media

Arjen Amelink, Martin P. L. Bard, Sjaak A. Burgers, and Henricus J. C. M. Sterenborg  »View Author Affiliations

Applied Optics, Vol. 42, Issue 19, pp. 4095-4101 (2003)

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We report on the development of an optical-fiber-based diagnostic tool that is sensitive to single-scattering events close to the fiber-optic probe tip. By using a single fiber to deliver and detect white light we optimized the detection probability of singly scattered photons from small depths. The sampling depth of this delivery-and-collection fiber was investigated by use of a tissue phantom. We found that for our phantom 90% of the single-scattering signal in the delivery-and-collection fiber originated from less than 200 μm from the fiber tip. The contribution of multiply scattered light from a greater depth to the signal was measured with an additional collection fiber. Several tissue phantoms demonstrated our fiber-optic probe’s sensitivity to light scattering from superficial layers of tissue and thereby its potential to detect superficial precancerous epithelial lesions.

© 2003 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media

Original Manuscript: December 12, 2002
Revised Manuscript: April 1, 2003
Published: July 1, 2003

Arjen Amelink, Martin P. L. Bard, Sjaak A. Burgers, and Henricus J. C. M. Sterenborg, "Single-scattering spectroscopy for the endoscopic analysis of particle size in superficial layers of turbid media," Appl. Opt. 42, 4095-4101 (2003)

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