Abstract
We report on the development of an optical-fiber-based diagnostic tool that is sensitive to single-scattering events close to the fiber-optic probe tip. By using a single fiber to deliver and detect white light we optimized the detection probability of singly scattered photons from small depths. The sampling depth of this delivery-and-collection fiber was investigated by use of a tissue phantom. We found that for our phantom 90% of the single-scattering signal in the delivery-and-collection fiber originated from less than 200 μm from the fiber tip. The contribution of multiply scattered light from a greater depth to the signal was measured with an additional collection fiber. Several tissue phantoms demonstrated our fiber-optic probe’s sensitivity to light scattering from superficial layers of tissue and thereby its potential to detect superficial precancerous epithelial lesions.
© 2003 Optical Society of America
Full Article | PDF ArticleMore Like This
Yasser S. Fawzy and Haishan Zeng
Appl. Opt. 45(16) 3902-3912 (2006)
Murat Canpolat and Judith R. Mourant
Appl. Opt. 40(22) 3792-3799 (2001)
Arjen Amelink and Henricus J. C. M. Sterenborg
Appl. Opt. 43(15) 3048-3054 (2004)