OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 42, Iss. 22 — Aug. 1, 2003
  • pp: 4612–4620

Comparison of Spatially and Temporally Resolved Diffuse-Reflectance Measurement Systems for Determination of Biomedical Optical Properties

Johannes Swartling, Jan S. Dam, and Stefan Andersson-Engels  »View Author Affiliations


Applied Optics, Vol. 42, Issue 22, pp. 4612-4620 (2003)
http://dx.doi.org/10.1364/AO.42.004612


View Full Text Article

Acrobat PDF (149 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Time-resolved and spatially resolved measurements of the diffuse reflectance from biological tissue are two well-established techniques for extracting the reduced scattering and absorption coefficients. We have performed a comparison study of the performance of a spatially resolved and a time-resolved instrument at wavelengths 660 and 785 nm and also of an integrating-sphere setup at 550–800 nm. The first system records the diffuse reflectance from a diode laser by means of a fiber bundle probe in contact with the sample. The time-resolved system utilizes picosecond laser pulses and a single-photon-counting detection scheme. We extracted the optical properties by calibration using known standards for the spatially resolved system, by fitting to the diffusion equation for the time-resolved system, and by using an inverse Monte Carlo model for the integrating sphere. The measurements were performed on a set of solid epoxy tissue phantoms. The results showed less than 10% difference in the evaluation of the reduced scattering coefficient among the systems for the phantoms in the range 9–20 cm−1, and absolute differences of less than 0.05 cm−1 for the absorption coefficient in the interval 0.05–0.30 cm−1.

© 2003 Optical Society of America

OCIS Codes
(120.3150) Instrumentation, measurement, and metrology : Integrating spheres
(120.5820) Instrumentation, measurement, and metrology : Scattering measurements
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

Citation
Johannes Swartling, Jan S. Dam, and Stefan Andersson-Engels, "Comparison of Spatially and Temporally Resolved Diffuse-Reflectance Measurement Systems for Determination of Biomedical Optical Properties," Appl. Opt. 42, 4612-4620 (2003)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-42-22-4612

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited