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Applied Optics

Applied Optics


  • Vol. 42, Iss. 25 — Sep. 1, 2003
  • pp: 5181–5190

Tomographic optical breast imaging guided by three-dimensional mammography

Ang Li, Eric L. Miller, Misha E. Kilmer, Thomas J. Brukilacchio, Tina Chaves, Jonathan Stott, Quan Zhang, Tao Wu, MaryAnn Chorlton, Richard H. Moore, Daniel B. Kopans, and David A. Boas  »View Author Affiliations

Applied Optics, Vol. 42, Issue 25, pp. 5181-5190 (2003)

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We introduce a modified Tikhonov regularization method to include three-dimensional x-ray mammography as a prior in the diffuse optical tomography reconstruction. With simulations we show that the optical image reconstruction resolution and contrast are improved by implementing this x-ray-guided spatial constraint. We suggest an approach to find the optimal regularization parameters. The presented preliminary clinical result indicates the utility of the method.

© 2003 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3830) Medical optics and biotechnology : Mammography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
(170.6960) Medical optics and biotechnology : Tomography

Original Manuscript: February 4, 2003
Revised Manuscript: May 19, 2003
Published: September 1, 2003

Ang Li, Eric L. Miller, Misha E. Kilmer, Thomas J. Brukilacchio, Tina Chaves, Jonathan Stott, Quan Zhang, Tao Wu, MaryAnn Chorlton, Richard H. Moore, Daniel B. Kopans, and David A. Boas, "Tomographic optical breast imaging guided by three-dimensional mammography," Appl. Opt. 42, 5181-5190 (2003)

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