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Applied Optics

Applied Optics


  • Vol. 42, Iss. 31 — Nov. 1, 2003
  • pp: 6412–6421

Breast cancer detection by mapping hemoglobin concentration and oxygen saturation

Xuefeng Cheng, Jian-min Mao, Robin Bush, Daniel B. Kopans, Richard H. Moore, and Maryann Chorlton  »View Author Affiliations

Applied Optics, Vol. 42, Issue 31, pp. 6412-6421 (2003)

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Near-infrared (NIR) spectroscopic imaging technology provides a new modality for measuring changes in total hemoglobin concentration (HbT) and blood oxygen saturation (SO2) in human tissue. The technology can be used to detect breast cancer because cancers may cause greater vascularization and greater oxygen consumption than in normal tissue. Based on the NIR technology, ViOptix, Inc., has developed an optical device that provides two-dimensional mapping of HbT and SO2 in human tissue. As an adjunctive tool to mammography, the device was preliminarily tested in a clinical trial with 50 mammogram-positive patients at the Massachusetts General Hospital. The results of the clinical trial demonstrate that the device can reach as much as 92% diagnostic sensitivity and 67% specificity in detecting ductal carcinoma. These results may indicate that the NIR technology can potentially be used as an adjunct to mammography for breast cancer detection to reduce the number of biopsies performed.

© 2003 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.7050) Medical optics and biotechnology : Turbid media

Original Manuscript: November 6, 2002
Revised Manuscript: May 28, 2003
Published: November 1, 2003

Xuefeng Cheng, Jian-min Mao, Robin Bush, Daniel B. Kopans, Richard H. Moore, and Maryann Chorlton, "Breast cancer detection by mapping hemoglobin concentration and oxygen saturation," Appl. Opt. 42, 6412-6421 (2003)

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