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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 42, Iss. 4 — Feb. 1, 2003
  • pp: 745–749

Determination of glucose in whole blood samples by mid-infrared spectroscopy

Yoen-Joo Kim, Sangjoon Hahn, and Gilwon Yoon  »View Author Affiliations


Applied Optics, Vol. 42, Issue 4, pp. 745-749 (2003)
http://dx.doi.org/10.1364/AO.42.000745


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Abstract

We have determined the glucose concentration of whole blood from mid-infrared spectra without sample preparation or use of chemical reagents. We selected 1119–1022 cm-1 as the optimal wavelength range for our measurement by making a first-loading vector analysis based on partial least-squares regression. We examined the influence of hemoglobin on samples by using different calibration right prediction sets. The accuracy of glucose prediction depended on the hemoglobin level in the calibration model; the sample set should represent the entire range of hemoglobin concentration. We obtained an accuracy of 5.9% in glucose prediction, and this value is well within a clinically acceptable range.

© 2003 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1580) Medical optics and biotechnology : Chemometrics
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

History
Original Manuscript: June 10, 2002
Revised Manuscript: September 26, 2002
Published: February 1, 2003

Citation
Yoen-Joo Kim, Sangjoon Hahn, and Gilwon Yoon, "Determination of glucose in whole blood samples by mid-infrared spectroscopy," Appl. Opt. 42, 745-749 (2003)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-42-4-745

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