Abstract

The development of an accurate and reliable noninvasive near-infrared (NIR) glucose sensor hinges on the success in addressing the sensitivity and the specificity problems associated with the weak glucose signals and the overlapping NIR spectra. Spectroscopic hardware parameters most relevant to noninvasive blood glucose measurement are discussed, which include the optical throughput, integration time, spectral range, and the spectral resolution. We propose a unique spectroscopic system using a continuously rotating interference filter, which produces a signal-to-noise ratio of the order of 10⁵ and is estimated to be the minimum required for successful in vivo glucose sensing. Using a classical least-squares algorithm and a spectral range between 2180 and 2312 nm, we extracted clinically relevant glucose concentrations in multicomponent solutions containing bovine serum albumin, triacetin, lactate, and urea.

© 2004 Optical Society of America

Phase-sensitive optical low-coherence reflectometry for the detection of analyte concentrations

Kirill V. Larin, Taner Akkin, Rinat O. Esenaliev, Massoud Motamedi, and Thomas E. Milner
Appl. Opt. 43(17) 3408-3414 (2004)

Noninvasive glucose monitoring in vivo with an optical heterodyne polarimeter

Chien Chou, Chien-Yuan Han, Wen-Chuan Kuo, Yeu-Chuen Huang, Ching-Mei Feng, and Jenn-Chyang Shyu
Appl. Opt. 37(16) 3553-3557 (1998)

Glucose sensing in oral mucosa simulating phantom using differential absorption based frequency domain low-coherence interferometry

Pauline John, Nilesh J. Vasa, Sujatha Narayanan Unni, and Suresh R. Rao
Appl. Opt. 56(29) 8257-8265 (2017)

Noninvasive glucose detection in human skin using wavelength modulated differential laser photothermal radiometry

Xinxin Guo, Andreas Mandelis, and Bernard Zinman
Biomed. Opt. Express 3(11) 3012-3021 (2012)

Correlation between blood glucose concentration in diabetics and noninvasively measured tissue optical scattering coefficient

J. T. Bruulsema, J. E. Hayward, T. J. Farrell, M. S. Patterson, L. Heinemann, M. Berger, T. Koschinsky, J. Sandahl-Christiansen, H. Orskov, M. Essenpreis, G. Schmelzeisen-Redeker, and D. Böcker
Opt. Lett. 22(3) 190-192 (1997)