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Applied Optics

Applied Optics


  • Vol. 43, Iss. 14 — May. 10, 2004
  • pp: 2868–2873

Microsurface plasmon resonance biosensing based on gold-nanoparticle film

Xin Hong and Fu-Jen Kao  »View Author Affiliations

Applied Optics, Vol. 43, Issue 14, pp. 2868-2873 (2004)

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We use a gold-nanoparticle coated film to achieve highly spatially resolved biosensing that is based on localized surface-plasmon resonance. Unlike the planar gold film employed for conventional surface-plasmon resonance sensing, the gold-nanoparticle film relies exclusively on shifting of the peak extinction wavelength for detection of biointeraction and does not depend critically on the angle of incidence. These characteristics permit integration of surface-plasmon resonance with large-numerical-aperture optics to achieve biosensing with high sensitivity and spatial resolution as high as 25 μm.

© 2004 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.0180) Medical optics and biotechnology : Microscopy
(240.6680) Optics at surfaces : Surface plasmons
(300.1030) Spectroscopy : Absorption

Original Manuscript: September 25, 2003
Revised Manuscript: February 17, 2004
Published: May 10, 2004

Xin Hong and Fu-Jen Kao, "Microsurface plasmon resonance biosensing based on gold-nanoparticle film," Appl. Opt. 43, 2868-2873 (2004)

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