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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 43, Iss. 14 — May. 10, 2004
  • pp: 2874–2883

Ultrahigh-resolution full-field optical coherence tomography

Arnaud Dubois, Kate Grieve, Gael Moneron, Romain Lecaque, Laurent Vabre, and Claude Boccara  »View Author Affiliations


Applied Optics, Vol. 43, Issue 14, pp. 2874-2883 (2004)
http://dx.doi.org/10.1364/AO.43.002874


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Abstract

We have developed a white-light interference microscope for ultrahigh-resolution full-field optical coherence tomography of biological media. The experimental setup is based on a Linnik-type interferometer illuminated by a tungsten halogen lamp. En face tomographic images are calculated by a combination of interferometric images recorded by a high-speed CCD camera. Spatial resolution of 1.8 μm × 0.9 μm (transverse × axial) is achieved owing to the extremely short coherence length of the source, the compensation of dispersion mismatch in the interferometer arms, and the use of relatively high-numerical-aperture microscope objectives. A shot-noise-limited detection sensitivity of 90 dB is obtained in an acquisition time per image of 4 s. Subcellular-level images of plant, animal, and human tissues are presented.

© 2004 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6900) Medical optics and biotechnology : Three-dimensional microscopy
(180.3170) Microscopy : Interference microscopy

History
Original Manuscript: September 30, 2003
Revised Manuscript: February 17, 2004
Published: May 10, 2004

Citation
Arnaud Dubois, Kate Grieve, Gael Moneron, Romain Lecaque, Laurent Vabre, and Claude Boccara, "Ultrahigh-resolution full-field optical coherence tomography," Appl. Opt. 43, 2874-2883 (2004)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-43-14-2874

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