We report on multidistance time-resolved diffuse reflectance spectroscopy of the head of a healthy adult after intravenous administration of a bolus of indocyanine green. Intracerebral and extracerebral changes in absorption are deduced from moments (integral, mean time of flight, and variance) of the distributions of times of flight of photons (DTOFs), recorded simultaneously at four different source-detector separations. We calculate the sensitivity factors converting depth-dependent changes in absorption into changes of moments of DTOFs by Monte Carlo simulations by using a layered model of the head. We validate our method by analyzing moments of DTOFs simulated for the assumed changes in absorption in different layers of the head model.
© 2004 Optical Society of America
Original Manuscript: September 1, 2003
Revised Manuscript: December 19, 2003
Published: May 20, 2004
Adam Liebert, Heidrun Wabnitz, Jens Steinbrink, Hellmuth Obrig, Michael Möller, Rainer Macdonald, Arno Villringer, and Herbert Rinneberg, "Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons," Appl. Opt. 43, 3037-3047 (2004)