OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 43, Iss. 3 — Jan. 20, 2004
  • pp: 542–554

Optical fiber probe for biomedical Raman spectroscopy

Jason T. Motz, Martin Hunter, Luis H. Galindo, Joseph A. Gardecki, John R. Kramer, Ramachandra R. Dasari, and Michael S. Feld  »View Author Affiliations


Applied Optics, Vol. 43, Issue 3, pp. 542-554 (2004)
http://dx.doi.org/10.1364/AO.43.000542


View Full Text Article

Enhanced HTML    Acrobat PDF (269 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

In vitro experiments have demonstrated the ability of Raman spectroscopy to diagnose a wide variety of diseases. Recent in vivo investigations performed with optical fiber probes were promising but generally limited to easily accessible organs, often requiring relatively long collection times. We have implemented an optical design strategy to utilize system throughput fully by characterizing the Raman distribution from tissue. This scheme optimizes collection efficiency, minimizes noise, and has resulted in small-diameter, highly efficient Raman probes that are capable of collecting high-quality data in 1 s. Performance has been tested through simulations and experiments with tissue models and several in vitro tissue types, demonstrating that this new design can advance Raman spectroscopy as a clinically practical technique.

© 2004 Optical Society of America

OCIS Codes
(060.2310) Fiber optics and optical communications : Fiber optics
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(170.5660) Medical optics and biotechnology : Raman spectroscopy

Citation
Jason T. Motz, Martin Hunter, Luis H. Galindo, Joseph A. Gardecki, John R. Kramer, Ramachandra R. Dasari, and Michael S. Feld, "Optical Fiber Probe for Biomedical Raman Spectroscopy," Appl. Opt. 43, 542-554 (2004)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-43-3-542

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited