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Applied Optics

Applied Optics


  • Vol. 43, Iss. 6 — Feb. 20, 2004
  • pp: 1320–1326

Signal dependence and noise source in ultrasound-modulated optical tomography

Gang Yao and Lihong V. Wang  »View Author Affiliations

Applied Optics, Vol. 43, Issue 6, pp. 1320-1326 (2004)

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A Monte Carlo modeling technique was used to simulate ultrasound-modulated optical tomography in inhomogeneous scattering media. The contributions from two different modulation mechanisms were included in the simulation. Results indicate that ultrasound-modulated optical signals are much more sensitive to small embedded objects than unmodulated intensity signals. The differences between embedded absorption and scattering objects in the ultrasound-modulated optical signals were compared. The effects of neighboring inhomogeneity and background optical properties on the ultrasound-modulated optical signals were also studied. We analyzed the signal-to-noise ratio in the experiment and found that the major noise source is the speckle noise caused by small particle movement within the biological tissue sample. We studied this effect by incorporating a Brownian motion factor in the simulation.

© 2004 Optical Society of America

OCIS Codes
(110.7050) Imaging systems : Turbid media
(110.7170) Imaging systems : Ultrasound
(120.6150) Instrumentation, measurement, and metrology : Speckle imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging

Original Manuscript: August 20, 2003
Revised Manuscript: November 17, 2003
Published: February 20, 2004

Gang Yao and Lihong V. Wang, "Signal dependence and noise source in ultrasound-modulated optical tomography," Appl. Opt. 43, 1320-1326 (2004)

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