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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 44, Iss. 10 — Apr. 1, 2005
  • pp: 1870–1878

Effects of refractive index on near-infrared tomography of the breast

Hamid Dehghani, Ben A. Brooksby, Brian W. Pogue, and Keith D. Paulsen  »View Author Affiliations


Applied Optics, Vol. 44, Issue 10, pp. 1870-1878 (2005)
http://dx.doi.org/10.1364/AO.44.001870


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Abstract

Near infrared (NIR) optical tomography is an imaging technique in which internal images of optical properties are reconstructed with the boundary measurements of light propagation through the medium. Recent advances in instrumentation and theory have led to the use of this method for the detection and characterization of tumors within the female breast tissue. Most image reconstruction approaches have used the diffusion approximation and have assumed that the refractive index of the breast is constant, with a bulk value of approximately 1.4. We have applied a previously reported modified diffusion approximation, in which the refractive index for different tissues can be modeled. The model was used to generate NIR data from a realistic breast geometry containing a localized anomaly. Using this simulated data, we have reconstructed optical images, both with and without correct knowledge of the refractive-index distribution to show that the modified diffusion approximation can accurately recover the anomaly given a priori knowledge of refractive index. But using a reconstruction algorithm without the use of correct a priori information regarding the refractive-index distribution is shown as recovering the anomaly but with a degraded quality, depending on the degree of refractive index mismatch. The results suggest that provided the refractive index of breast tissue is approximately 1.3-1.4, their exclusion will have minimal effect on the reconstructed images.

© 2005 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3830) Medical optics and biotechnology : Mammography
(170.6960) Medical optics and biotechnology : Tomography

Citation
Hamid Dehghani, Ben A. Brooksby, Brian W. Pogue, and Keith D. Paulsen, "Effects of refractive index on near-infrared tomography of the breast," Appl. Opt. 44, 1870-1878 (2005)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-44-10-1870


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References

  1. H. Dehghani, B. W. Pogue, S. P. Poplack, and K. D. Paulsen, "Multiwavelength three-dimensional near-infrared tomography of the breast: initial simulation, phantom, and clinical results," Appl. Opt.  42, 135-145 (2003).
  2. S. Fantini, S. A. Walker, M. A. Franceschini, M. Kaschke, P. M. Schlag, and K. T. Moesta, "Assessment of the size, position, and optical properties of breast tumors in vivo by noninvasive optical methods," Appl. Opt.  37, 1982-1989 (1998).
  3. J. Hebden, A. Gibson, T. Austin, R. Yusof, N. Everdell, D. Delpy, S. Arridge, J. Meek, and J. Wyatt, "Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography," Phys. Med. Biol.  49, 1117-1130 (2004).
  4. B. Chance, "Near-infrared (NIR) optical spectroscopy characterizes breast tissue hormonal and age status," Acad. Radiol.  8, 209-210 (2001).
  5. J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti, and F. Martelli, "Assessment of an in situ temporal calibration method for time-resolved optical tomography," J. Biomed. Opt.  8, 87-92 (2003).
  6. A. Y. Bluestone, G. Abdoulaev, C. Schmitz, R. L. Barbour, and A. H. Hielscher, "Three-dimensional optical-tomography of hemodynamics in the human head," Opt. Express  9, 272-286 (2001), http://www.opticsexpress.org.
  7. E. M. C. Hillman, J. C. Hebden, M. Schweiger, H. Dehghani, F. E. W. Schmidt, D. T. Delpy, and S. R. Arridge, "Time resolved optical tomography of the human forearm," Phys. Med. Biol.  46, 1117-1130 (2001).
  8. H. Xu, H. Dehghani, B. W. Pogue, R. Springett, K. D. Paulsen, and J. Dunn, "Near-infrared imaging in the small animal brain: optimization of fiber positions," J. Biomed. Opt.  8, 102-110 (2003).
  9. T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast," J. Biomed. Opt.  7, 72-79 (2002).
  10. S. R. Arridge, "Optical tomography in medical imaging," Inv. Probl.  15, R41-R93 (1999).
  11. H. Dehghani, B. Brooksby, K. Vishwanath, B. W. Pogue, and K. D. Paulsen, "The effects of internal refractive index variation in near-infrared optical tomography: a finite element modelling approach," Phys. Med. Biol.  48, 2713-2727 (2003).
  12. H. Jiang and Y. Xu, "Phase-contrast imaging of tissue using near-infrared diffusing light," Med. Phys.  30, 1048-1051 (2003).
  13. J. H. Lee, S. Kim, and Y. T. Kim, "Finite element method for diffusive light propagations in index-mismatched media," Opt. Express  12, 1727-1740 (2004), http://www.opticsexpress.org.
  14. B. Brooksby, H. Dehghani, K. Vishwanath, B. W. Pogue, and K. D. Paulsen, "Internal refractive index changes affect light transport in tissue," in Optical Tomography and Spectroscopy of Tissue V, B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, and E. M. Sevick-Muraca, eds., Proc. SPIE  4955, 296-304 (2003).
  15. F. P. Bolin, L. E. Preuss, R. C. Taylor, and R. J. Ference, "Refractive index of some mammalian tissue using a fiber optic cladding method," Appl. Opt.  28, 2297-2303 (1989).
  16. B. J. Tromberg, O. Coquoz, J. B. Fishkin, T. Pham, E. R. Anderson, J. Butler, M. Cahn, J. D. Gross, V. Venugopalan, and D. Pham, "Non-invasive measurements of breast tissue optical properties using frequency-domain photon migration," Phil. Trans. R. Soc. Lond. B  352, 661-668 (1997).
  17. S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "Interpreting hemoglobin and water concentration, oxygen saturation and scattering measured in vivo by near-infrared breast tomography," Proc. Natl. Acad. Sci. USA  100, 12349-12354 (2003).
  18. B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, S. P. Poplack, and K. D. Paulsen, "Characterization of hemoglobin, water and NIR scattering in breast tissue: analysis of inter-subject variability and menstrual cycle changes relative to lesions," J. Biomed. Opt.  9, 541-552 (2004).
  19. B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum.  75, 5262-5270 (2004).
  20. M. Schweiger, S. R. Arridge, M. Hiroaka, and D. T. Delpy, "The finite element model for the propagation of light in scattering media: boundary and source conditions," Med. Phys.  22, 1779-1792 (1995).
  21. J. M. Schmitt, G. X. Zhou, E. C. Walker, and R. T. Wall, "Multilayer model of photon diffusion in skin," J. Opt. Soc. Am. A  7, 2141-2153 (1990).
  22. S. Takatani and M. Graham, "Theoretical analysis of diffuse reflectance from a two-layer tissue model," IEEE Trans. Biomed. Eng.  26, 656-664 (1979).
  23. G. W. Faris, "Diffusion equation boundary conditions for the interface between turbid media: a comment," J. Opt. Soc. Am. A  19, 519-520 (2002).
  24. H. Jiang, K. D. Paulsen, U. L. Osterberg, B. W. Pogue, and M. S. Patterson, "Optical image reconstruction using frequency-domain data: simulations and experiments," J. Opt. Soc. Am. A  13, 253-266 (1996).
  25. S. R. Arridge, M. Schweiger, M. Hiraoka, and D. T. Delpy, "A finite element approach for modeling photon transport in tissue," Med. Phys.  20, 299-309 (1993).
  26. S. R. Arridge and M. Schweiger, "Photon-measurement density functions. Part 2: Finite-element-method calculations," Appl. Opt.  34, 8026-8037 (1995).
  27. T. O. McBride, B. W. Pogue, U. L. Osterberg, and K. D. Paulsen, "Strategies for absolute calibration of near infrared tomographic tissue imaging," in Oxygen Transport to Tissue XXIV, J. F. Dunn and H. M. Schwartz, eds., Adv. Exp. Med. Biol.  531, 85-99 (2003).
  28. T. McBride, "Spectroscopic reconstructed near infrared tomographic imaging for breast cancer diagnosis," Ph.D. dissertation (Dartmouth College, Hanover, 2001).

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