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Applied Optics

Applied Optics


  • Vol. 44, Iss. 11 — Apr. 10, 2005
  • pp: 2019–2023

Rapid optical coherence tomography and recording functional scattering changes from activated frog retina

Xin-Cheng Yao, Angela Yamauchi, Beth Perry, and John S. George  »View Author Affiliations

Applied Optics, Vol. 44, Issue 11, pp. 2019-2023 (2005)

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Optical coherence tomography (OCT) has important potential advantages for fast functional neuroimaging. However, dynamic neuroimaging poses demanding requirements for fast and stable acquisition of optical scans. Optical phase modulators based on the electro-optic effect allow rapid phase modulation; however, applications to low-coherence tomography are limited by the optical dispersion of a broadband light source by the electro-optic crystal. We show that the optical dispersion can be theoretically estimated and experimentally compensated. With an electro-optic phase modulator–based, no-moving-parts OCT system, near-infrared scattering changes associated with neural activation were recorded from isolated frog retinas activated by visible light.

© 2005 Optical Society of America

OCIS Codes
(120.5060) Instrumentation, measurement, and metrology : Phase modulation
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(290.5820) Scattering : Scattering measurements

Original Manuscript: August 31, 2004
Revised Manuscript: December 6, 2004
Manuscript Accepted: December 13, 2004
Published: April 10, 2005

Xin-Cheng Yao, Angela Yamauchi, Beth Perry, and John S. George, "Rapid optical coherence tomography and recording functional scattering changes from activated frog retina," Appl. Opt. 44, 2019-2023 (2005)

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