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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 44, Iss. 11 — Apr. 10, 2005
  • pp: 2024–2032

Spectroscopic imaging for detection of ischemic injury in rat kidneys by use of changes in intrinsic optical properties

Andromachi P. Michalopoulou, Jason T. Fitzgerald, Christoph Troppmann, and Stavros G. Demos  »View Author Affiliations


Applied Optics, Vol. 44, Issue 11, pp. 2024-2032 (2005)
http://dx.doi.org/10.1364/AO.44.002024


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Abstract

It is currently impossible to consistently predict kidney graft viability and function before and after transplantation. We explored optical spectroscopy to assess the degree of ischemic damage in kidney tissue. Tunable UV laser excitation was used to record autofluorescence images, at different spectral ranges, of injured and contralateral control rat kidneys to reveal the excitation conditions that offered optimal contrast. Autofluorescence and near-infrared cross-polarized light-scattering imaging were both used to monitor changes in intensity and spectral characteristics, as a function of exposure time to ischemic injury. These two modalities provided different temporal behaviors, arguably arising from two different mechanisms providing direct correlation of intrinsic optical signatures to ischemic injury time.

© 2005 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

History
Original Manuscript: July 14, 2004
Revised Manuscript: September 24, 2004
Manuscript Accepted: October 20, 2004
Published: April 10, 2005

Citation
Andromachi P. Michalopoulou, Jason T. Fitzgerald, Christoph Troppmann, and Stavros G. Demos, "Spectroscopic imaging for detection of ischemic injury in rat kidneys by use of changes in intrinsic optical properties," Appl. Opt. 44, 2024-2032 (2005)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-44-11-2024

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