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Applied Optics

Applied Optics


  • Vol. 44, Iss. 11 — Apr. 10, 2005
  • pp: 2082–2093

Diffuse optical tomography with spectral constraints and wavelength optimization

Alper Corlu, Regine Choe, Turgut Durduran, Kijoon Lee, Martin Schweiger, Simon R. Arridge, Elizabeth M. C. Hillman, and Arjun G. Yodh  »View Author Affiliations

Applied Optics, Vol. 44, Issue 11, pp. 2082-2093 (2005)

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We present an algorithm that explicitly utilizes the wavelength dependence of tissue optical properties for diffuse optical tomography. We have previously shown that the method gives superior separation of absorption and scattering. Here the technique is described and tested in detail, and optimum wavelength sets for a broad range of chromophore combinations are discovered and analyzed.

© 2005 Optical Society of America

OCIS Codes
(100.3190) Image processing : Inverse problems
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3830) Medical optics and biotechnology : Mammography
(170.5280) Medical optics and biotechnology : Photon migration
(170.6960) Medical optics and biotechnology : Tomography

Original Manuscript: July 26, 2004
Revised Manuscript: November 13, 2004
Manuscript Accepted: November 15, 2004
Published: April 10, 2005

Alper Corlu, Regine Choe, Turgut Durduran, Kijoon Lee, Martin Schweiger, Simon R. Arridge, Elizabeth M. C. Hillman, and Arjun G. Yodh, "Diffuse optical tomography with spectral constraints and wavelength optimization," Appl. Opt. 44, 2082-2093 (2005)

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  1. A. Yodh, B. Chance, “Spectroscopy and imaging with diffusing light,” Phys. Today, 48, 34–40 (1995). [CrossRef]
  2. A. G. Yodh, D. A. Boas, “Functional imaging with diffusing light,” in Biomedical Photonics (CRC Press, Boca Raton, Fla., 2003), Chap. 21, pp. 1–45.
  3. J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, D. N. Pattanayak, B. Chance, A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys. 30, 235–247 (2003). [CrossRef] [PubMed]
  4. A. E. Cerussi, A. J. Berger, F. Bevilacqua, N. Shah, D. Jakubowski, J. Butler, R. F. Holcombe, B. J. Tromberg, “Sources of absorption and scattering contrast for near-infrared optical mammography,” Acad. Radiol. 8, 211–218 (2001). [CrossRef] [PubMed]
  5. T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, A. G. Yodh, “Bulk optical properties of healthy female breast tissue,” Phys. Med. Biol. 47, 2847–2861 (2002). [CrossRef] [PubMed]
  6. T. O. McBride, B. W. Pogue, S. D. Jiang, U. L. Osterberg, “A parallel-detection frequency-domain near-infrared tomography system for hemoglobin imaging of the breast in vivo,” Rev. Sci. Instrum. 72, 1817–1824 (2001). [CrossRef]
  7. V. Ntziachristos, B. Chance, “Probing physiology and molecular function using optical imaging: applications to breast cancer,” Breast Cancer Res. Treatment 3, 41–46 (2001). [CrossRef]
  8. V. Ntziachristos, A. G. Yodh, M. Schnall, B. Chance, “Concurrent mri and diffuse optical tomography of breast after Indocyanine Green enhancement,” Proc. Natl. Acad. USA 97, 2767–2772 (2000). [CrossRef]
  9. B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, K. D. Paulsen, “Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast,” Radiology 218, 261–266 (2001). [CrossRef] [PubMed]
  10. N. Shah, A. Cerussi, C. Eker, J. Espinoza, J. Butler, J. Fishkin, R. Hornung, B. Tromberg, “Noninvasive functional optical spectroscopy of human breast tissue,” Proc. Natl. Acad. Sci. USA 98, 4420–4425 (2001).
  11. D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18, 57–75 (2001). [CrossRef]
  12. J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003). [CrossRef] [PubMed]
  13. D. M. Hueber, M. A. Franceschini, H. Y. Ma, Q. Zhang, J. R. Ballesteros, S. Fantini, D. Wallace, V. Ntziachristos, B. Chance, “Non-invasive and quantitative near-infrared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrument,” Phys. Med. Biol. 46, 41–62 (2001). [CrossRef] [PubMed]
  14. B. W. Pogue, K. D. Paulsen, “High-resolution near-infrared tomographic imaging simulations of the rat cranium by use of apriori magnetic resonance imaging structural information,” Opt. Lett. 23, 1716–1718 (1998). [CrossRef]
  15. B. Chance, M. T. Dait, C. Zhang, T. Hamaoka, F. Hagerman, “Recovery from excercise-induced desaturation in the quadriceps muscles of elite competitive rowers,” Am. J. Physiol. 262, C766–C775 (1992). [PubMed]
  16. R. Belardinelli, T. J. Barstow, J. Porszasz, K. Wasserman, “Skeletal muscle oxygenation during constant work rate exercise,” Med. Sci. Sports Exercise 27, 512–519 (1995). [CrossRef]
  17. K. W. Rundell, S. Nioka, B. Chance, “Haemoglobin/ myoglobin desaturation during speed skating.” Med. Sci. Sports. Exercise 29, 248–258 (1997). [CrossRef]
  18. H. Otaga, T. Yumoki, T. Yano, “Effect of arm cranking on the NIRS determined blood volume and oxygenation of human inactive and exercising vastus lateralis muscle,” J. Appl. Physiol. 86, 191–195 (2002). [CrossRef]
  19. B. C. Wilson, M. S. Patterson, S. T. Flock, “Indirect versus direct techniques for the measurement of the optical properties of tissues,” Photochem. Photobiol. 46, 601–608 (1987). [CrossRef] [PubMed]
  20. H. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64, 7553–7561 (2004). [CrossRef] [PubMed]
  21. S. R. Arridge, W. R. B. Lionheart, “Nonuniqueness in diffusion-based optical tomography,” Opt. Lett. 23, 882–884 (1998). [CrossRef]
  22. Y. Pei, H. L. Graber, R. L. Barbour, “Normalized– constraint algorithm for minimizing inter–parameter crosstalk in dc optical tomography,” Opt. Express 9, 97–109 (2001), http://www.opticsexpress.org . [CrossRef] [PubMed]
  23. H. L. Graber, Y. Pei, R. L. Barbour, “Imaging of spatiotemporal coincident states by dc optical tomography,” IEEE Trans Med. Imaging 21, 852–866 (2002). [CrossRef] [PubMed]
  24. C. H. Schmitz, M. Löcker, J. M. Lasker, A. H. Hielscher, R. L. Barbour, “Instrumentation for fast functional optical tomography,” Rev. Sci. Instrum. 73, 429–439 (2002). [CrossRef]
  25. Y. Xu, X. Gu, T. Khan, H. Jiang, “Absorption and scattering images of heterogenous scattering media can be simultaneously reconstructed by use of dc data,” Appl. Opt. 41, 5427–5437 (2002). [CrossRef] [PubMed]
  26. E. M. C. Hillman, “Experimental and theoretical investigations of near infrared tomographic imaging methods and clinical applications,” Ph.D. thesis (University College London, 2002).
  27. A. Corlu, T. Durduran, R. Choe, M. Schweiger, E. M. C. Hillman, S. R. Arridge, A. G. Yodh, “Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography,” Opt. Lett. 28, 2339–2341 (2003). [CrossRef] [PubMed]
  28. A. Li, Q. Zhang, J. P. Culver, E. L. Miller, D. Boas, “Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography,” Opt. Lett. 29, 256–258 (2004). [CrossRef] [PubMed]
  29. T. Durduran, A. G. Yodh, B. Chance, D. A. Boas, “Does the photon diffusion coefficient depend on absorption?” J. Opt. Soc. Am. A. 14, 3358–3365 (1997). [CrossRef]
  30. D. J. Durian, “The diffusion coefficient depends on absorption,” Opt. Lett. 23, 1502–1504 (1998). [CrossRef]
  31. M. Schweiger, S. R. Arridge, M. Hiraoka, D. T. Delpy, “The finite element model for the propagation of light in scattering media: boundary and source conditions,” Med. Phys. 22, 1779–1792 (1995). [CrossRef] [PubMed]
  32. F. Bevilacqua, A. J. Berger, A. E. Cerussi, D. Jakubowski, B. J. Tromberg, “Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods,” Appl. Opt. 39, 6498–6507 (2000). [CrossRef]
  33. J. R. Mourant, T. Fuselier, J. Boyer, T. M. Johnson, I. J. Bigio, “Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms,” Appl. Opt. 36, 949–957 (1997). [CrossRef] [PubMed]
  34. M. A. O'Leary, “Imaging with diffuse photon density waves,” Ph.D. dissertation (University of Pennsylvania, Philadelphia, Pennsylvania, 1996).
  35. S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41–R93 (1999). [CrossRef]
  36. S. R. Arridge, M. Schweiger, “A gradient-based optimisation scheme for optical tomography,” Opt. Express 2, 213–226 (1998), http://www.opticsexpress.org . [CrossRef] [PubMed]
  37. S. J. Wright, J. Nocedal, eds., Numerical Optimization (Springer-Verlag, New York, 2000).
  38. L. N. Trefethen, D. Bau, eds., Numerical Linear Algebra (Society for Industrial and Applied Mathematics, Philadelphia, 1997). [CrossRef]
  39. S. Prahl, “Optical properties spectra,” retrieved 16March2003, http://omlc.ogi.edu/spectra/index.html , 2001.
  40. S. R. Arridge, M. Schweiger, M. Hiraoka, D. T. Delpy, “A finite element approach for modeling photon transport in tissue,” Med. Phys. 20, 299–309 (1993). [CrossRef] [PubMed]
  41. T. Durduran, “Non-invasive measurements of tissue hemodynamics with hybrid diffuse optical methods,” Ph.D. dissertation (University of Pennsylvania, Philadelphia, 2004).
  42. B. W. Pogue, T. O. McBride, J. Prewit, K. D. Osterberg, U. L. Paulsen, “Spatially variant regularization improves diffuse optical tomography,” Appl. Opt. 38, 2950–2961 (1999). [CrossRef]
  43. D. R. White, H. Q. Woodward, S. M. Hammond, “Average soft-tissue and bone models for use in radiation dosimetry,” Br. J. Radiol. 60, 907–913 (1987). [CrossRef] [PubMed]
  44. H. Q. Woodward, D. R. White, “The composition of body tissues,” Br. J. Radiol. 59, 1209–1219 (1986). [CrossRef]

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