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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 44, Iss. 11 — Apr. 10, 2005
  • pp: 2213–2220

In vivo absorption spectroscopy of tumor sensitizers with femtosecond white light

Claes af Klinteberg, Antonio Pifferi, Stefan Andersson-Engels, Rinaldo Cubeddu, and Sune Svanberg  »View Author Affiliations


Applied Optics, Vol. 44, Issue 11, pp. 2213-2220 (2005)
http://dx.doi.org/10.1364/AO.44.002213


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Abstract

A system based on a femtosecond white-light continuum and a streak camera was used for recordings of the in vivo absorption spectra of the tumor-seeking agent disulphonated aluminum phthalocyanine. Measurements for different drug doses were performed on tumor tissue (muscle-implanted adenocarcinoma) and normal muscle tissue in rats. It was found that the shape of the spectrum is tissue dependent. The peak of the absorption spectrum is blueshifted in tumor tissue as compared with the muscle. Thus the contrast in the drug-related absorption can be altered by up to a factor of 2 from the primary drug molecular-concentration contrast between normal muscle and tumor by the proper selection of the illumination wavelength.

© 2005 Optical Society of America

OCIS Codes
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

History
Original Manuscript: July 7, 2004
Revised Manuscript: December 5, 2004
Manuscript Accepted: December 6, 2004
Published: April 10, 2005

Citation
Claes af Klinteberg, Antonio Pifferi, Stefan Andersson-Engels, Rinaldo Cubeddu, and Sune Svanberg, "In vivo absorption spectroscopy of tumor sensitizers with femtosecond white light," Appl. Opt. 44, 2213-2220 (2005)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-44-11-2213


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