Understanding the propagation of polarized light in tissue is crucial for a number of biomedical optics applications. Here we report the development of a bioengineered connective tissue model fabricated by the combination of scaffolding and cross-linking techniques to study light transport in biological tissue. It demonstrates great similarity to real connective tissue in its optical properties as well as microarchitecture. Moreover, the optical properties of the model can be reproducibly controlled. As an example, we report the utilization of this model to study the effect of epithelium and the underlying connective tissue on the depth selectivity of polarization gating.
© 2005 Optical Society of America
Original Manuscript: June 17, 2004
Revised Manuscript: October 8, 2004
Manuscript Accepted: October 15, 2004
Published: April 20, 2005
Yang Liu, Young L. Kim, and Vadim Backman, "Development of a bioengineered tissue model and its application in the investigation of the depth selectivity of polarization gating," Appl. Opt. 44, 2288-2299 (2005)