A system for interstitial photodynamic therapy with delta-aminolaevulinic acid and multiple optical fibers has been developed. The system enables photodynamic treatment of large embedded tumor volumes and utilizes real-time measurements to allow on-line dosimetry. Important parameters such as light fluence rate, sensitizer fluorescence intensity, and changes in local blood oxygen saturation are measured with the same fibers that deliver the therapeutic light. Data from the first clinical treatments on nodular basal cell carcinomas indicate a major treatment-induced light absorption increase, rapid sensitizer photobleaching, and a relatively constant global tissue oxygen saturation level during the treatment.
© 2005 Optical Society of America
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.1460) Medical optics and biotechnology : Blood gas monitoring
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
Marcelo Soto Thompson, Ann Johansson, Thomas Johansson, Stefan Andersson-Engels, Sune Svanberg, Niels Bendsoe, and Katarina Svanberg, "Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements," Appl. Opt. 44, 4023-4031 (2005)