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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 44, Iss. 20 — Jul. 10, 2005
  • pp: 4265–4271

Transillumination optical tomography of tissue-engineered blood vessels: a Monte Carlo simulation

Gang Yao and Mark A. Haidekker  »View Author Affiliations


Applied Optics, Vol. 44, Issue 20, pp. 4265-4271 (2005)
http://dx.doi.org/10.1364/AO.44.004265


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Abstract

A Monte Carlo technique has been developed to simulate the transillumination laser computed tomography of tissue-engineered blood vessels. The blood vessel was modeled as a single cylinder layer mounted on a tubular mandrel. Sequences of images were acquired while rotating the mandrel. The tomographic image was reconstructed by applying a standard Radon transform. Angular discrimination was applied to simulate a spatial filter, which was used to reject multiply scattered photons. The simulation results indicated that the scattering effect can be overcome with angular discrimination because of the thin tissue thickness. However, any refractive-index mismatch among the tissue, the surrounding media, and the mandrel could produce significant distortions in the reconstructed image.

© 2005 Optical Society of America

OCIS Codes
(110.6960) Imaging systems : Tomography
(120.7000) Instrumentation, measurement, and metrology : Transmission
(170.0110) Medical optics and biotechnology : Imaging systems
(290.0290) Scattering : Scattering

History
Original Manuscript: August 31, 2004
Revised Manuscript: January 19, 2005
Manuscript Accepted: February 25, 2005
Published: July 10, 2005

Citation
Gang Yao and Mark A. Haidekker, "Transillumination optical tomography of tissue-engineered blood vessels: a Monte Carlo simulation," Appl. Opt. 44, 4265-4271 (2005)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-44-20-4265

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