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Applied Optics

Applied Optics


  • Vol. 44, Iss. 20 — Jul. 10, 2005
  • pp: 4265–4271

Transillumination optical tomography of tissue-engineered blood vessels: a Monte Carlo simulation

Gang Yao and Mark A. Haidekker  »View Author Affiliations

Applied Optics, Vol. 44, Issue 20, pp. 4265-4271 (2005)

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A Monte Carlo technique has been developed to simulate the transillumination laser computed tomography of tissue-engineered blood vessels. The blood vessel was modeled as a single cylinder layer mounted on a tubular mandrel. Sequences of images were acquired while rotating the mandrel. The tomographic image was reconstructed by applying a standard Radon transform. Angular discrimination was applied to simulate a spatial filter, which was used to reject multiply scattered photons. The simulation results indicated that the scattering effect can be overcome with angular discrimination because of the thin tissue thickness. However, any refractive-index mismatch among the tissue, the surrounding media, and the mandrel could produce significant distortions in the reconstructed image.

© 2005 Optical Society of America

OCIS Codes
(110.6960) Imaging systems : Tomography
(120.7000) Instrumentation, measurement, and metrology : Transmission
(170.0110) Medical optics and biotechnology : Imaging systems
(290.0290) Scattering : Scattering

Original Manuscript: August 31, 2004
Revised Manuscript: January 19, 2005
Manuscript Accepted: February 25, 2005
Published: July 10, 2005

Gang Yao and Mark A. Haidekker, "Transillumination optical tomography of tissue-engineered blood vessels: a Monte Carlo simulation," Appl. Opt. 44, 4265-4271 (2005)

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  1. R. M. Nerem, A. E. Ensley, “The tissue engineering of blood vessels and the heart,” Am. J. Transplant. 4, 36–42 (2004). [CrossRef] [PubMed]
  2. N. L’Heureux, J. C. Stoclet, F. A. Auger, G. J. L. Lagaud, L. Germain, R. Andriantsitohaina, “A human tissue-engineered vascular media: a new model for pharmacological studies of contractile response,” FASEB J. 15, 515–524 (2001). [CrossRef]
  3. R. H. Schmedlen, W. M. Elbjeirami, A. S. Gobin, J. L. West, “Tissue engineered small-diameter vascular grafts,” Clin. Plast. Surg. 30, 507–517 (2003). [CrossRef] [PubMed]
  4. R. R. Alfano, J. G. Fujimoto, eds., Advances in Optical Imaging and Photon Migration, Vol. 2 of Topics in Optics and Photonics Series (Optical Society of America, Washington, D.C., 1996).
  5. B. Chance, R. R. Alfano, eds., Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, Proc. SPIE2979, 1997.
  6. B. Das, K. Yoo, R. R. Alfano, “Ultrafast time gated imaging,” Opt. Lett. 18, 1092–1094 (1993). [CrossRef]
  7. S. Marengo, C. Pepin, T. Goulet, D. Houde, “Time-gated transillumination of objects in highly scattering media using a subpicosecond optical amplifier,” IEEE J. Sel. Top. Quantum Electron. 5, 895–901 (1999). [CrossRef]
  8. Y. Tetsuya, S. Tanosaki, Y. Sasaki, M. Takagi, A. Ishikawa, H. Taniguchi, B. Devaraj, T. Akatsuka, “Fundamental imaging properties of transillumination laser computed tomography based on coherence detection imaging method,” Anal. Sci. 18, 1329–1333 (2002). [CrossRef]
  9. J. C. Gladish, G. Yao, N. L’Heureux, M. A. Haidekker, “Optical transillumination tomography for imaging of tissue-engineered blood vessels,” Ann. Biomed. Eng. 33, 323–327 (2005). [CrossRef] [PubMed]
  10. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 178–1181 (1991). [CrossRef]
  11. D. Y. Churmakov, I. V. Meglinski, D. A. Greenhalgh, “Amending of fluorescence sensor signal localization in human skin by matching of the refractive index,” J. Biomed. Opt. 9, 339–346 (2004). [CrossRef] [PubMed]
  12. Y. Otani, T. Shimada, T. Yoshizawa, N. Umeda, “Two-dimensional birefringence measurement using the phase shifting technique,” Opt. Eng. 33, 1604–1609 (1994). [CrossRef]
  13. L. Wang, S. L. Jacques, L. Zheng, “MCML–Monte Carlo modeling of light transport in multi-layered tissues,” Comput. Methods Programs Biomed. 47, 131–146 (1995). [CrossRef] [PubMed]
  14. L. Henyey, J. Greenstein, “Diffuse radiation in the galaxy,” Astrophys. J. 93, 70–83 (1941). [CrossRef]
  15. L. A. Shepp, J. B. Kruskal, “Computerized tomography: the new medical x-ray technology,” Am. Math. Monthly 85, 420–439 (1978). [CrossRef]
  16. J. M. C. van Gemert, R. M. Verdaasdonk, E. G. Stassen, G. Schets, “Optical properties of human blood vessel wall and plaque,” Lasers Surg. Med. 5, 235–273 (1985). [CrossRef] [PubMed]

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