We describe a high-resolution real-time spectroscopy system targeted to ethane gas with sensitivity ≥70 ppt and response time from ≥0.7 s. The measurement technique is based on a mid-IR lead-salt laser passing through a Herriott cell through which a gas sample flows. We compare wavelength scanning and locked configurations and discuss their relative merits. The technology has been motivated by clinical breath testing applications, ethane being widely regarded as the most important breath biomarker for cell damage via free-radical-mediated oxidative attack. We discuss preliminary human and animal studies in which ultrasensitive real-time ethane detection offers new diagnostic and monitoring potential.
© 2005 Optical Society of America
Original Manuscript: July 20, 2004
Revised Manuscript: October 20, 2004
Manuscript Accepted: December 15, 2004
Published: August 1, 2005
Kenneth D. Skeldon, Graham M. Gibson, Cathy A. Wyse, Lesley C. McMillan, Steve D. Monk, Chris Longbottom, and Miles J. Padgett, "Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science," Appl. Opt. 44, 4712-4721 (2005)