OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 44, Iss. 22 — Aug. 1, 2005
  • pp: 4722–4732

Micro-optical fiber probe for use in an intravascular Raman endoscope

Yuichi Komachi, Hidetoshi Sato, Katsuo Aizawa, and Hideo Tashiro  »View Author Affiliations


Applied Optics, Vol. 44, Issue 22, pp. 4722-4732 (2005)
http://dx.doi.org/10.1364/AO.44.004722


View Full Text Article

Enhanced HTML    Acrobat PDF (390 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We believe that we have developed the narrowest optical-fiber Raman probe ever reported, 600 μm in total diameter, that can be inserted into coronary arteries. The selection of suitable optical fibers, filters, and a processing method is discussed. Custom-made filters attached to the front end of a probe eliminate the background Raman signals of the optical fiber itself. The experimental evaluation of various optical fibers is carried out for the selection of suitable fibers. Measurement of the Raman spectra of an atherosclerotic lesion of a rabbit artery in vitro demonstrates the excellent performance of the micro-Raman probe.

© 2005 Optical Society of America

OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.5660) Medical optics and biotechnology : Raman spectroscopy

History
Original Manuscript: June 3, 2004
Revised Manuscript: November 15, 2004
Manuscript Accepted: February 24, 2005
Published: August 1, 2005

Citation
Yuichi Komachi, Hidetoshi Sato, Katsuo Aizawa, and Hideo Tashiro, "Micro-optical fiber probe for use in an intravascular Raman endoscope," Appl. Opt. 44, 4722-4732 (2005)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-44-22-4722


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. H. A. Crispin, A. F. Van Baarle, “Intravascular observation and surgery using the flexible fiberscope,” Lancet 1, 750–751 (1973). [CrossRef] [PubMed]
  2. M. Takano, K. Mizuno, S. Yokoyama, K. Seimiya, F. Ishibashi, K. Okamatsu, R. Uemura, “Changes in coronary plaque color and morphology by lipid-lowering therapy with atorvastatin: serial evaluation by coronary angioscopy,” J. Am. Coll. Cardiol. 42, 680–686 (2003). [CrossRef] [PubMed]
  3. G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I.-K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107, 113–119 (2003). [CrossRef] [PubMed]
  4. S. Achenbach, F. Moselewski, D. Ropers, M. Ferencik, U. Hoffmannm, B. MacNeill, K. Pohle, U. Baum, K. Anders, I.-K. Jang, W. G. Daniel, T. J. Brady, “Detection of calcified and noncalcified coronary atherosclerotic plaque by contrast-enhanced submillimeter multidetector spiral computed tomography a segment-based comparison with intravascular ultrasound,” Circulation 109, 14–17 (2004). [CrossRef]
  5. R. Manoharan, J. J. Baraga, M. S. Feld, R. P. Rava, “Quantitative histochemical analysis of human artery using Raman spectroscopy,” J. Photochem. Photobiol. B 16, 211–233 (1992). [CrossRef] [PubMed]
  6. E. B. Hanlon, R. Manoharan, T-W. Koo, K. E. Shafer, J. T. Motz, M. Fitzmaurice, J. R. Kramer, I. Itzkan, R. R. Dasari, M. S. Feld, “Prospects for in vivo Raman spectroscopy,” Phys. Med. Biol. 45, R1–R59 (2000). [CrossRef] [PubMed]
  7. T. J. Romer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. W. van der Steen, N. A. Bom, A. V. G. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20, 478–483 (2000). [CrossRef] [PubMed]
  8. K. P. J. Williams, “Remote sampling using a fiber-optic probe in Fourier transform Raman spectroscopy,” J. Raman. Spectrosc. 21, 147–151 (1989). [CrossRef]
  9. J. Ma, Y.-S. Li, “Fiber Raman background study and its application in setting up optical fiber Raman probes,” Appl. Opt. 35, 2527–2533 (1996). [CrossRef] [PubMed]
  10. I. R. Lewis, P. R. Griffiths, “Raman spectrometry with fiber-optic sampling,” Appl. Spectrosc. 50, 12A–30A (1996). [CrossRef]
  11. T. F. Cooney, H. T. Skinner, S. M. Angel, “Comparative study of some fiber-optic remote Raman probe designs, Part I: model for liquids and transparent solids,” Appl. Spectrosc. 50, 836–848 (1996). [CrossRef]
  12. M. G. Shim, B. C. Wilson, “Development of an in vivo Raman spectroscopic system for diagnostic applications,” J. Raman Spectrosc. 28, 131–142 (1997). [CrossRef]
  13. A. Mahadevan-Jansen, M. F. Mitchell, N. Ramanujam, A. Malpica, S. Thomsen, U. Utzinger, R. Richards-Kortum, “Development of a fiber optic probe to measure NIR Raman spectra of cervical tissue in vivo ,” Photochem. Photobiol. 68, 427–431 (1998). [CrossRef] [PubMed]
  14. M. G. Shim, B. C. Wilson, E. Marple, M. Wach, “Study of fiber-optic probes for in vivo medical Raman spectroscopy,” Appl. Spectrosc. 53, 619–627 (1999). [CrossRef]
  15. S. Christensen, B. MacIver, L. Procell, D. Sorrick, M. Carrabba, J. Bello, “Nonintrusive analysis of chemical agent identification sets using a portable fiber-optic Raman spectrometer,” Appl. Spectrosc. 53, 850–855 (1999). [CrossRef]
  16. S. Brown, F. P. Milanovich, K. Kyle, “Design of a conepenetrometer-compatible probe and housing: the LLNL Raman probe,” Rev. Sci. Instrum. 70, 3735–3743 (1999). [CrossRef]
  17. M. Wach, B. Bennett, T. C. Bakker Schut, H. A. Bruining, A. V. Bruschke, A. van der Laarse, G. J. Puppels, “In vivo determination of the molecular composition of artery wall by intravascular Raman spectroscopy,” Anal. Chem. 72, 3771–3775 (2000). [CrossRef] [PubMed]
  18. C. J. de Lima, S. Sathaiah, L. Silveira, R. A. Zângaro, M. T. T. Pacheco, “Development of catheters with low fiber background signals for Raman spectroscopic diagnosis applications,” Artif. Organs 24, 231–234 (2000). [CrossRef] [PubMed]
  19. H. P. Buschman, E. T. Marple, M. L. Wach, B. Bennett, T. C. Bakker Schut, H. A. Bruining, A. V. Bruschke, A. van der Laarse, G. J. Puppels, “In vivo determination of the molecular composition of artery wall by intravascular Raman spectroscopy,” Anal. Chem. 72, 3771–3775 (2000). [CrossRef] [PubMed]
  20. M. G. Shim, L.-M. W. K. Song, N. E. Marcon, B. C. Wilson, “In vivo near-infrared Raman spectroscopy: demonstration of feasibility during clinical gastrointestinal endoscopy,” Photochem. Photobiol. 72, 146–150 (2000). [PubMed]
  21. U. Utzinger, D. L. Heintzelman, A. Mahadevan-Jansen, A. Malpica, M. Follen, R. Richards-Kortum, “Near-infrared Raman spectroscopy for in vivo detection of cervical precancers,” Appl. Spectrosc. 55, 955–959 (2001). [CrossRef]
  22. H. Sato, T. Tanaka, T. Ikeda, S. Wada, H. Tashiro, Y. Ozaki, “Biomedical applications of a new portable Raman imaging probe,” J. Mol. Struct. 598, 93–96 (2001). [CrossRef]
  23. R. L. McCreery, Raman Spectroscopy for Chemical Analysis (Wiley, 2000), pp. 333–371.
  24. J. T. Motz, M. Hunter, L. H. Galindo, J. A. Gardecki, J. R. Kramer, R. R. Dasari, M. S. Feld, “Optical fiber probe for biomedical Raman spectroscopy,” Appl. Opt. 43, 542–554 (2004). [CrossRef] [PubMed]
  25. H. Sato, S. Wada, Y. Ozaki, H. Tashiro, “Qualitative analysis of trace Raman bands of nonresonant species in near-infrared excited preresonance Raman spectra of hemoglobin by partial least-square regression-Raman excitation profile method,” Vib. Spectrosc. 34, 149–156 (2004). [CrossRef]
  26. H. Sato, S. Wada, M. Ling, H. Tashiro, “Noninvasive measurement of near-infrared transmission spectra of a whole human hand with an electronically tuned Ti:sapphire laser operated by dual radio frequency driving method,” Appl. Spectrosc. 54, 1163–1167 (2000). [CrossRef]
  27. H. Sato, S. Wada, H. Tashiro, “Fluorescence background-free Ti:sapphire laser using acousto-optical tunable filter for Raman spectroscopic measurements,” Appl. Spectrosc. 56, 1303–1307 (2002). [CrossRef]
  28. H. Sato, H. Chiba, H. Tashiro, Y. Ozaki, “Excitation wavelength-dependent changes in Raman spectra of whole blood and hemoglobin: comparison of the spectra with 514.5-, 720-, and 1064-nm excitation,” J. Biomed. Opt. 6, 366–370 (2001). [CrossRef] [PubMed]
  29. R. Manoharan, J. J. Baraga, M. S. Feld, R. P. Rava, “Quantitative histochemical analysis of human artery using Raman spectroscopy,” J. Photochem. Photobiol. B 16, 211–233 (1992). [CrossRef] [PubMed]
  30. J. Hayashi, T. Saito, K. Aizawa, “Change in chemical composition of lipids accumulated in atheromas of rabbits following photodynamic therapy,” Lasers Surg. Med. 21, 287–293 (1997). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited