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Applied Optics

Applied Optics


  • Vol. 44, Iss. 24 — Aug. 22, 2005
  • pp: 5055–5068

Semiconductor laser insert with uniform illumination for use in photodynamic therapy

Ivan Charamisinau, Gemunu Happawana, Gary Evans, Arye Rosen, Richard A. His, and David Bour  »View Author Affiliations

Applied Optics, Vol. 44, Issue 24, pp. 5055-5068 (2005)

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A low-cost semiconductor red laser light delivery system for esophagus cancer treatment is presented. The system is small enough for insertion into the patient’s body. Scattering elements with nanoscale particles are used to achieve uniform illumination. The scattering element optimization calculations, with Mie theory, provide scattering and absorption efficiency factors for scattering particles composed of various materials. The possibility of using randomly deformed spheres and composite particles instead of perfect spheres is analyzed using an extension to Mie theory. The measured radiation pattern from a prototype light delivery system fabricated using these design criteria shows reasonable agreement with the theoretically predicted pattern.

© 2005 Optical Society of America

OCIS Codes
(140.5960) Lasers and laser optics : Semiconductor lasers
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(220.4830) Optical design and fabrication : Systems design
(290.4020) Scattering : Mie theory
(290.5850) Scattering : Scattering, particles
(290.5880) Scattering : Scattering, rough surfaces

Original Manuscript: April 8, 2004
Revised Manuscript: April 6, 2005
Manuscript Accepted: April 15, 2005
Published: August 20, 2005

Ivan Charamisinau, Gemunu Happawana, Gary Evans, Arye Rosen, Richard A. His, and David Bour, "Semiconductor laser insert with uniform illumination for use in photodynamic therapy," Appl. Opt. 44, 5055-5068 (2005)

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