Abstract

An easy and accurate assessment of the renal function is a critical requirement for detecting the initial functional decline of the kidney induced by acute or chronic renal disease. A method for measuring the glomerular filtration rate is developed with the accuracy of clearance techniques and the convenience of plasma creatinine. The renal function is measured in rats as the rate of clearance determined from time-resolved transcutaneous fluorescence measurements of a new fluorescent glomerular filtration agent. The agent has a large dose-safety coefficient and the same space distribution and clearance characteristics as iothalamate. This new approach is a convenient and accurate way to perform real-time measurements of the glomerular filtration rate to detect early kidney disease before the renal function becomes severely and irreversibly compromised.

© 2005 Optical Society of America

Interband cascade laser absorption sensor for real-time monitoring of formaldehyde filtration by a nanofiber membrane

Chenyu Yao, Zhen Wang, Qiang Wang, Ye Bian, Chun Chen, Li Zhang, and Wei Ren
Appl. Opt. 57(27) 8005-8010 (2018)

Reagent- and separation-free measurements of urine creatinine concentration using stamping surface enhanced Raman scattering (S-SERS)

Ming Li, Yong Du, Fusheng Zhao, Jianbo Zeng, Chandra Mohan, and Wei-Chuan Shih
Biomed. Opt. Express 6(3) 849-858 (2015)

Optical techniques for real-time penetration monitoring for laser welding

Fabrice Bardin, Adolfo Cobo, Jose M. Lopez-Higuera, Olivier Collin, Pascal Aubry, Thierry Dubois, Mats Högström, Per Nylen, Peter Jonsson, Julian D. C. Jones, and Duncan P. Hand
Appl. Opt. 44(19) 3869-3876 (2005)

In vivo longitudinal 920 nm two-photon intravital kidney imaging of a dynamic 2,8-DHA crystal formation and tubular deterioration in the adenine-induced chronic kidney disease mouse model

Jieun Choi, Min-Sun Choi, Jehwi Jeon, Jieun Moon, Jingu Lee, Eunji Kong, Stephani Edwina Lucia, Sujung Hong, Ji-Hye Lee, Eun Young Lee, and Pilhan Kim
Biomed. Opt. Express 14(4) 1647-1658 (2023)

Use of surface-enhanced Raman scattering as a prognostic indicator of acute kidney transplant rejection

Jingmao Chi, Thet Zaw, Iliana Cardona, Mujtaba Hosnain, Neha Garg, Heather R. Lefkowitz, Peter Tolias, and Henry Du
Biomed. Opt. Express 6(3) 761-769 (2015)