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Applied Optics

Applied Optics


  • Vol. 44, Iss. 3 — Jan. 20, 2005
  • pp: 348–357

Direct bidirectional angle-insensitive imaging of the flow signal intensity in Doppler optical coherence tomography

Daqing Piao and Quing Zhu  »View Author Affiliations

Applied Optics, Vol. 44, Issue 3, pp. 348-357 (2005)

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We introduce a new method, to our knowledge, for direct detection of flow signal intensity by stationary target rejection. In our system, two delay lines are constructed with identical scanning speed and ranging depth. One delay line is used for depth ranging as well as phase modulation, and the other one acts as a full-range retroreflector (FRRR). The signal from this FRRR carries the overall features of local phase modulation, and it is used as the local oscillator for coherent demodulation. With this setup, stationary targets can be rejected at a 4-kHz high-pass cutoff frequency of the filter that follows the demodulator, compared with 20 kHz for conventional fixed-frequency demodulation. This technique features angle insensitivity and provides flow direction as well by implementing standard in-phase and quadrature detection. Besides the direct directional detection of flow signal intensity, flow speed information can be acquired with postprocessing.

© 2005 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

Original Manuscript: February 2, 2004
Revised Manuscript: July 9, 2004
Manuscript Accepted: August 2, 2004
Published: January 20, 2005

Daqing Piao and Quing Zhu, "Direct bidirectional angle-insensitive imaging of the flow signal intensity in Doppler optical coherence tomography," Appl. Opt. 44, 348-357 (2005)

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  1. X. J. Wang, T. E. Milner, J. S. Nelson, “Characterization of fluid flow velocity by optical Doppler tomography,” Opt. Lett. 20, 1337–1339 (1995). [CrossRef] [PubMed]
  2. Z. P. Chen, T. E. Milner, S. Srinivas, X. J. Wang, A. Malekafzali, M. J. C. van Germert, J. S. Nelson, “Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography,” Opt. Lett. 22, 1119–1121 (1997). [CrossRef] [PubMed]
  3. J. A. Izatt, M. D. Kulkarni, S. Yazdanfar, J. K. Barton, A. J. Welch, “In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography,” Opt. Lett. 22, 1439–1441 (1997). [CrossRef]
  4. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991). [CrossRef] [PubMed]
  5. A. M. Rollins, S. Yazdanfar, J. K. Barton, J. A. Izatt, “Real-time in vivo color Doppler optical coherence tomography,” J. Biomed. Opt. 7, 123–129 (2002). [CrossRef] [PubMed]
  6. H. Ren, K. M. Brecke, Z. Ding, Y. Zhao, J. S. Nelson, Z. Chen, “Imaging and quantifying transverse flow velocity with the Doppler bandwidth in a phase-resolved functional optical coherence tomography,” Opt. Lett. 27, 409–411 (2002). [CrossRef]
  7. D. Piao, Q. Zhu, “Quantifying Doppler angle and mapping flow velocity by a combination of Doppler-shift and Doppler-bandwidth measurements in optical Doppler tomography,” Appl. Opt. 42, 5158–5168 (2003). [CrossRef] [PubMed]
  8. H. Ren, Y. Wang, J. S. Nelson, Z. Chen, “Power optical Doppler tomography imaging of blood vessel in human skin and M-mode Doppler imaging of blood flow in chick chrioallantoic membrane,” in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII, V. V. Tuchin, J. A. Izatt, J. G. Fujimoto, eds., Proc. SPIE4956, 225–231 (2003). [CrossRef]
  9. V. W. Westphal, S. Yazdanfar, A. M. Rollins, J. A. Izatt, “Real-time, high velocity-resolution color Doppler optical coherence tomography,” Opt. Lett. 27, 34–36 (2002). [CrossRef]
  10. Y. Zhao, Z. Chen, Z. Ding, H. Ren, J. S. Nelson, “Real-time phase-resolved functional optical coherence tomography by use of optical Hilbert transformation,” Opt. Lett. 27, 98–100 (2002). [CrossRef]
  11. S. Yan, D. Piao, Y. Chen, Q. Zhu, “Digital signal processor–based real-time optical Doppler tomography system,” J. Biomed. Opt. 9, 454–463 (2004). [CrossRef] [PubMed]
  12. A. V. Zvyagin, J. B. FitzGerald, K. K. M. B. D. Silva, D. D. Sampson, “Real-time detection technique for Doppler optical coherence tomography,” Opt. Lett. 25, 1645–1647 (2000). [CrossRef]
  13. H. Dehghani, B. Brooksby, K. Vishwanath, B. W. Pogue, K. D. Paulsen, “The effect of internal refractive index variation in near-infrared optical tomography: a finite element modeling approach,” Phys. Med. Biol. 48, 2713–2727 (2003). [CrossRef] [PubMed]
  14. V. L. Newhouse, E. S. Furgason, G. F. Johnson, D. A. Wolf, “The dependence of ultrasound Doppler bandwidth on beam geometry,” IEEE Trans. Sonics Ultrason. SU-27, 50–59 (1980). [CrossRef]
  15. V. X. D. Yang, M. L. Gordon, B. Qi, J. Pekar, S. Lo, E. SengYue, A. Mok, B. C. Wilson, I. A. Vitkin, “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part I): system design, signal processing, and performance,” Opt. Express 11, 794–809 (2003). [CrossRef] [PubMed]
  16. A. M. Rollins, S. Yazdabfar, S. Radhakrishnan, V. Westphal, M. V. Sivak, J. A. Izatt, “Real-time imaging of microstructure and blood flows using optical coherence tomography,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE, Bellingham, Wash., 2002).
  17. S. Yazdanfar, J. A. Izatt, “Self-referenced Doppler optical coherence tomography,” Opt. Lett. 27, 2085–2087 (2002). [CrossRef]
  18. T. Shiina, Y. Moritani, M. Ito, Y. Okamura, “Long-optical-path scanning mechanism for optical coherence tomography,” Appl. Opt. 42, 3795–3799 (2003). [CrossRef] [PubMed]
  19. Y. Zhao, Z. Chen, C. Saxer, S. Xiang, J. F. de Boer, J. S. Nelson, “Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity,” Opt. Lett. 25, 114–116 (2000). [CrossRef]
  20. N. G. Chen, Q. Zhu, “Rotary mirror array for high-speed optical coherence tomography,” Opt. Lett. 27, 607–609 (2002). [CrossRef]
  21. G. J. Tearney, B. E. Bouma, J. G. Fujimoto, “High-speed phase- and group-delay scanning with a grating-based phase control delay line,” Opt. Lett. 22, 1811–1813 (1997). [CrossRef]
  22. D. Piao, Q. Zhu, “Power-efficient grating-based scanning optical delay line: time-domain configuration,” Electron. Lett. 40, 97–98 (2004). [CrossRef]
  23. A. V. Zvyagin, E. D. J. Smith, D. D. Sampson, “Delay and dispersion characteristics of a frequency-domain optical delay line for scanning interferometry,” J. Opt. Soc. Am. A 20, 333–341 (2003). [CrossRef]
  24. A. M. Rollins, M. D. Kulkarni, S. Yazdanfar, R. Ungarunyawee, J. A. Izatt, “In vivo video rate optical coherence tomography,” Opt. Express 3, 219–229 (1998). [CrossRef] [PubMed]
  25. D. Piao, L. L. Otis, N. K. Dutta, Q. Zhu, “Quantitative assessment of flow velocity-estimation algorithms for optical Doppler tomography imaging,” Appl. Opt. 41, 6118–6127 (2002). [CrossRef] [PubMed]

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