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Applied Optics

Applied Optics


  • Vol. 44, Iss. 3 — Jan. 20, 2005
  • pp: 366–377

Low-coherent backscattering spectroscopy for tissue characterization

Young L. Kim, Yang Liu, Ramesh K. Wali, Hemant K. Roy, and Vadim Backman  »View Author Affiliations

Applied Optics, Vol. 44, Issue 3, pp. 366-377 (2005)

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Although the phenomenon of coherent backscattering (CBS) in nonbiological media has generated substantial research interest, observing CBS in biological tissue has been extremely difficult. Here we show that the combination of low-spatial-coherence, broadband illumination, and low-temporal-coherence, spectrally resolved detection significantly facilitates CBS observation in biological tissue and other random media with long-transport mean-free path lengths, which have been previously beyond the reach of conventional CBS investigations. Furthermore, we demonstrate that depth-selective, speckle-free, low-coherent backscattering spectroscopy has the potential to diagnose the earliest, previously undetectable, precancerous alterations in the colon by means of probing short light paths.

© 2005 Optical Society of America

OCIS Codes
(030.1670) Coherence and statistical optics : Coherent optical effects
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(290.1350) Scattering : Backscattering
(300.6170) Spectroscopy : Spectra

Original Manuscript: June 15, 2004
Revised Manuscript: October 7, 2004
Manuscript Accepted: October 7, 2004
Published: January 20, 2005

Young L. Kim, Yang Liu, Ramesh K. Wali, Hemant K. Roy, and Vadim Backman, "Low-coherent backscattering spectroscopy for tissue characterization," Appl. Opt. 44, 366-377 (2005)

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