We compare results for the number-weighted mean radius and polydispersity obtained either by directly fitting number distributions to dynamic light-scattering data or by converting results obtained by fitting intensity-weighted distributions. We find that results from fits using number distributions are angle independent and that converting intensity-weighted distributions is not always reliable, especially when the polydispersity of the sample is large. We compare the results of fitting symmetric and asymmetric distributions, as represented by Gaussian and Schulz distributions, respectively, to data for extruded vesicles and find that the Schulz distribution provides a better estimate of the size distribution for these samples.
© 2006 Optical Society of America
Photon Correlation and Scattering
Original Manuscript: November 4, 2005
Revised Manuscript: November 30, 2005
Manuscript Accepted: November 30, 2005
Philipus J. Patty and Barbara J. Frisken, "Direct determination of the number-weighted mean radius and polydispersity from dynamic light-scattering data," Appl. Opt. 45, 2209-2216 (2006)