OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 45, Iss. 2 — Jan. 10, 2006
  • pp: 335–342

Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy

Michael P. Siegel, Young L. Kim, Hemant K. Roy, Ramesh K. Wali, and Vadim Backman  »View Author Affiliations


Applied Optics, Vol. 45, Issue 2, pp. 335-342 (2006)
http://dx.doi.org/10.1364/AO.45.000335


View Full Text Article

Enhanced HTML    Acrobat PDF (409 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We report the feasibility of monitoring both hemoglobin oxygen saturation and hemoglobin concentration in the superficial layer of tissue using polarization-gated elastic light-scattering spectroscopy. We detail our analysis technique, the experimental validation of our analysis, and the detection of an early increase in blood supply to the superficial layer of colon tissue in human patients with colonic adenomas as well as in an animal model of colon carcinogenesis. To the best of our knowledge, this study represents the first evidence that polarization gating can be used as a spectroscopic tool to quantify hemoglobin concentration as well as oxygen saturation in the uppermost tissue layer.

© 2006 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(290.1350) Scattering : Backscattering

ToC Category:
Medical Optics and Biotechnology

Virtual Issues
Vol. 1, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Michael P. Siegel, Young L. Kim, Hemant K. Roy, Ramesh K. Wali, and Vadim Backman, "Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy," Appl. Opt. 45, 335-342 (2006)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-45-2-335


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. P. Vaupel, O. Thews, and M. Hoeckel, "Treatment resistance of solid tumors: role of hypoxia and anemia," Med. Oncol. 18, 243-259 (2001). [CrossRef]
  2. E. L. Hull and T. H. Foster, "Noninvasive near-infrared hemoglobin spectroscopy for in vivo monitoring of tumor-oxygenation and response to oxygen modifiers," in Proc. SPIE 2979, 355-364 (1997). [CrossRef]
  3. H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, "Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome," Cancer Res. 64, 7553-7651 (2004). [CrossRef] [PubMed]
  4. P. Vaupel and L. Harrison, "Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response," Oncologist 9, (Suppl. 5)4-9 (2004). [CrossRef] [PubMed]
  5. A. K. Dunn, A. Devor, H. Bolay, M. L. Andermann, M. A. Moskowitz, A. M. Dale, and D. A. Boas, "Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation," Opt. Lett. 28, 28-30 (2003). [CrossRef] [PubMed]
  6. H. Liu, D. A. Boas, Y. Zhang, A. G. Yodh, and B. Chance, "Determination of optical properties of blood oxygenation in tissue using continuous NIR light," Phys. Med. Biol. 40, 1983-1993 (1995). [CrossRef] [PubMed]
  7. S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplac, and K. D. Paulsen, "Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography," Proc. Natl. Acad. Sci. USA 100, 12349-12354 (2003). [CrossRef] [PubMed]
  8. S. J. Matcher and C. E. Cooper, "Absolute quantification of deoxyhaemoglobin concentration in tissue near infrared spectroscopy," Phys. Med. Biol. 39, 1295-1312 (1994). [CrossRef] [PubMed]
  9. T. J. Farrell and M. S. Patterson, "A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the non-invasive determination of tissue optical properties in vivo," Med. Phys. 19, 879-888 (1992). [CrossRef] [PubMed]
  10. V. Venugopalan, J. S. You, and B. J. Tromberg, "Radiative transport in the diffusion approximation: an extension for highly absorbing media and small source-detector separations," Phys. Rev. E 58, 2395-2407 (1998). [CrossRef]
  11. S. Fantini, M. A. Franceschini, and E. Gratton, "Semi-infinite-geometry boundary problem for the light migration in highly scattering media: a frequency-domain study in the diffusion approximation," J. Opt. Soc. Am. B 11, 2128-2138 (1994). [CrossRef]
  12. A. Kienle, L. Lilge, M. S. Patterson, R. Hibst, R. Steiner, and B. C. Wilson, "Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue," Appl. Opt. 35, 2304-2314 (1996). [CrossRef] [PubMed]
  13. J. R. Mourant, T. Fuselier, J. Boyer, T. M. Johnson, and I. J. Bigio, "Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms," Appl. Opt. 36, 949-957 (1997). [CrossRef] [PubMed]
  14. J. R. Mourant, T. M. Johnson, G. Los, and I. J. Bigio, "Non-invasive measurements of chemotherapy drug concentrations in tissue: preliminary demonstrations of in vivo measurements," Phys. Med. Biol. 44, 1397-1417 (1999). [CrossRef] [PubMed]
  15. W. T. Knoefel, N. Kollias, D. W. Rattner, N. S. Nishioka, and A. L. Warshaw, "Reflectance spectroscopy of pancreatic microcirculation," J. Appl. Physiol. 80, 116-123 (1996). [PubMed]
  16. G. Zonios, L. T. Perelman, V. Backman, R. Manoharan, M. Fitzmaurice, J. Van Dam, and M. S. Feld, "Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo," Appl. Opt. 38, 6628-6637 (1999). [CrossRef]
  17. A. A. Strantonnikov and V. B. Loschenov, "Evaluation of blood oxygenation in vivo from diffuse reflectance spectra," J. Biomed. Opt. 6, 457-467 (2001). [CrossRef]
  18. M. A. Franceschini, S. Fantini, L. A. Paunescu, J. S. Maier, and E. Gratton, "Influence of a superficial layer in the quantitative spectroscopic study of strongly scattering media," Appl. Opt. 37, 7447-7458 (1998). [CrossRef]
  19. A. Amelink and H. J. C. M. Sterenborg, "Measurement of the local optical properties of turbid media by differential path-length spectroscopy," Appl. Opt. 43, 3048-3054 (2004). [CrossRef] [PubMed]
  20. A. Amelink, H. J. C. M. Sterenborg, M. P. L. Bard, and S. A. Burgers, "In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy," Opt. Lett. 29, 1087-1089 (2004). [CrossRef] [PubMed]
  21. Y. L. Kim, Y. Liu, R. K. Wali, H. K. Roy, M. J. Goldberg, A. K. Kromin, K. Chen, and V. Backman, "Simultaneous measurement of angular and spectral properties of light scattering for characterization of tissue microarchitecture and its alterations in early precancer," IEEE J. Sel. Top. Quantum Electron. 9, 243-255 (2003). [CrossRef]
  22. Y. Liu, Y. L. Kim, X. Li, and V. Backman, "Investigation of depth selectivity of polarization gating for tissue characterization," Opt. Express 13, 601-611 (2005). [CrossRef] [PubMed]
  23. S. L. Jacques, J. C. Ramella-Roman, and K. Lee, "Imaging skin pathology with polarized light," J. Biomed. Opt. 7, 329-340 (2002). [CrossRef] [PubMed]
  24. J. M. Schmitt, A. H. Gandjbakhche, and R. F. Bonner, "Use of polarized light to discriminate short-path photons in a multiply scattering medium," Appl. Opt. 31, 6535-6546 (1992). [CrossRef] [PubMed]
  25. V. Backman, R. Gurjar, K. Badizadegan, L. Itzkan, R. R. Dasari, L. T. Perelman, and M. S. Feld, "Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ," IEEE J. Sel. Top. Quantum Electron. 5, 1019-1026 (1999). [CrossRef]
  26. A. Myakov, L. Nieman, L. Wicky, U. Utzinger, R. Richards-Kortum, and K. Sokolov, "Fiber optic probe for polarized reflectance spectroscopy in vivo: design and performance," J. Biomed. Opt. 7, 388-397 (2002). [CrossRef] [PubMed]
  27. R. K. Wali, H. K. Roy, Y. L. Kim, Y. Liu, J. L. Koestier, D. P. Kunte, M. J. Goldberg, V. Turzhitsky, and V. Backman, "Increased microvascular blood content is an early event in colon carcinogenesis," Gut 54, 654-660 (2005). [CrossRef] [PubMed]
  28. V. P. Dick, "Applicability of Beer's law for dispersion media with a high concentration of particles," Appl. Opt. 37, 4998-5004 (1998). [CrossRef]
  29. H. C. van de Hulst, Light Scattering by Small Particles (Dover, 1995).
  30. G. R. Kelman, "Digital computer subroutine for the conversion of oxygen tension into saturation," J. Appl. Physiol. 21, 1375-1376 (1966). [PubMed]
  31. R. Marchesini, A. Bertoni, S. Andreola, E. Melloni, and A. E. Sichirollo, "Extinction and absorption coefficients and scattering phase functions of human tissues in vitro," Appl. Opt. 28, 2318-2324 (1989). [CrossRef] [PubMed]
  32. T. Collier, A. Dizem, A. Malpica, M. Follen, and R. Richards-Kortum, "Determination of epithelial tissue scattering coefficient using confocal microscopy," IEEE J. Sel. Top. Quantum Electron. 9, 307-313 (2003). [CrossRef]
  33. W. F. Cheong, S. A. Prahl, and A. J. Welch, "A review of the optical properties of biological tissues," IEEE J. Quantum Electron. 26, 2166-2185 (1990). [CrossRef]
  34. J. F. Beek, P. Blokland, P. Posthumus, M. Aalders, J. W. Pickering, H. J. C. M. Sterenborg, and M. J. C. van Gemert, "In vitro double-integrating-sphere optical properties of tissues between 630 and 1064 nm," Phys. Med. Biol. 42, 2255-2261 (1997). [CrossRef] [PubMed]
  35. J. C. Finlay and T. H. Foster, "Effect of pigment packaging on diffuse reflectance spectroscopy of samples containing red blood cells," Opt. Lett. 29, 965-967 (2004). [CrossRef] [PubMed]
  36. R. L. P. van Veen, W. Verkruysse, and H. J. C. M. Sterenborg, "Diffuse-reflectance spectroscopy from 500 to 1060 nm by correction for inhomogeneously distributed absorbers," Opt. Lett. 27, 246-248 (2002). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited