Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy
Applied Optics, Vol. 45, Issue 2, pp. 335-342 (2006)
http://dx.doi.org/10.1364/AO.45.000335
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Abstract
We report the feasibility of monitoring both hemoglobin oxygen saturation and hemoglobin concentration in the superficial layer of tissue using polarization-gated elastic light-scattering spectroscopy. We detail our analysis technique, the experimental validation of our analysis, and the detection of an early increase in blood supply to the superficial layer of colon tissue in human patients with colonic adenomas as well as in an animal model of colon carcinogenesis. To the best of our knowledge, this study represents the first evidence that polarization gating can be used as a spectroscopic tool to quantify hemoglobin concentration as well as oxygen saturation in the uppermost tissue layer.
© 2006 Optical Society of America
OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(290.1350) Scattering : Backscattering
ToC Category:
Medical Optics and Biotechnology
Virtual Issues
Vol. 1, Iss. 2 Virtual Journal for Biomedical Optics
Citation
Michael P. Siegel, Young L. Kim, Hemant K. Roy, Ramesh K. Wali, and Vadim Backman, "Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy," Appl. Opt. 45, 335-342 (2006)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-45-2-335
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