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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 45, Iss. 3 — Jan. 20, 2006
  • pp: 489–494

Correction method for absorption-dependent signal enhancement by a liquid-core optical fiber

Dahu Qi and Andrew J. Berger  »View Author Affiliations


Applied Optics, Vol. 45, Issue 3, pp. 489-494 (2006)
http://dx.doi.org/10.1364/AO.45.000489


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Abstract

The enhancement of a dissolved chemical's Raman scattering by a liquid-core optical fiber (LCOF) geometry is absorption dependent. This dependence leads to a disruption of the usual linear correlation between chemical concentration and Raman peak area. To recover the linearity, we augmented a standard LCOF Raman spectroscopy system with spectrophotometric capabilities, permitting sequential measurements of Raman and absorption spectra within the LCOF. Measurements of samples with identical Raman-scatterer concentrations but different absorption coefficients are described. Using the absorption values, we reduced variations in the measured Raman intensities from 60 % to less than 1 % . This correction method should be important for LCOF-based Raman spectroscopy of sample sets with variable absorption coefficients, such as urine and blood serum from multiple patients.

© 2006 Optical Society of America

OCIS Codes
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(300.6450) Spectroscopy : Spectroscopy, Raman

ToC Category:
Spectroscopy

Virtual Issues
Vol. 1, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Dahu Qi and Andrew J. Berger, "Correction method for absorption-dependent signal enhancement by a liquid-core optical fiber," Appl. Opt. 45, 489-494 (2006)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-45-3-489


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References

  1. G. W. Walrafen and J. Stone, "Intensification of spontaneous Raman spectra by use of liquid core optical fibers," Appl. Spectrosc. 26, 585-589 (1972). [CrossRef]
  2. E. I. du Pont de Nemours and Company, "Amorphous copolymer of perfluoro-2, 2-dimethyll, 3-dioxole," U.S. patent 4,754,009 (4 September 1988).
  3. R. Altkorn, M. Duval Malinsky, R. P. Van Duyne, and I. Koev, "Intensity considerations in liquid core optical fiber Raman spectroscopy," Appl. Spectrosc. 55, 373-381 (2001). [CrossRef]
  4. L. Song, S. Liu, V. Zhelyaskov, and M. A. El-Sayed, "Application of liquid waveguide to Raman spectroscopy in aqueous solution," Appl. Spectrosc. 52, 1364-1367 (1998). [CrossRef]
  5. R. Altkorn, I. Koev, R. P. V. Duyne, and M. Litorja, "Low-loss liquid-core optical fiber for low-refractive-index liquids: fabrication, characterization, and application in Raman spectroscopy," Appl. Opt. 36, 8992-8998 (1997). [CrossRef]
  6. R. Altkorn, I. Koev, and M. J. Pelletier, "Raman performance characteristics of Teflon-AF 2400 liquid-core optical-fiber sample cells," Appl. Spectrosc. 53, 1169-1176 (1999). [CrossRef]
  7. P. Dress and H. Franke, "A cylindrical liquid-core waveguide," Appl. Phys. B 63, 12-19 (1996). [CrossRef]
  8. D. Qi and A. J. Berger, "Quantitative analysis of Raman signal enhancement from aqueous samples in liquid core optical fibers," Appl. Spectrosc. 58, 1165-1171 (2004). [CrossRef] [PubMed]
  9. M. J. Pelletier and R. Altkorn, "Raman sensitivity enhancement for aqueous protein samples using a liquid core optical-fiber cell," Anal. Chem. 73, 1393-1397 (2001). [CrossRef] [PubMed]
  10. D. Qi and A. J. Berger, "Quantitative concentration measurements of creatinine dissovled in water and urine using Raman spectroscopy and a liquid core optical fiber," J. Biomed. Opt. 10, 031115 (2005). [CrossRef] [PubMed]
  11. D. M. Haalnd and E. V. Thomas, "Partial least-squares methods for spectral analysis. 1. Relation to other quantitative calibration methods and the extraction of quantitative information," Anal. Chem. 60, 1193-1202 (1988). [CrossRef]
  12. D. M. Haaland and E. V. Thomas, "Partial least-squares methods for spectral analysis. 2. Application to simulated and glass spectra data," Anal. Chem. 60, 1202-1208 (1988). [CrossRef]
  13. R. Altkorn, I. Koev, and A. Gottlieb, "Waveguide capillary cell for low-refractive-index liquids," Appl. Spectrosc. 51, 1554-1558 (1997). [CrossRef]
  14. L. H. Kou, D. Labrie, and P. Chylek, "Refractive indices of water and ice in the 0.65 µm to 2.5 µm spectral range," Appl. Opt. 32, 3531-3540 (1993). [CrossRef] [PubMed]

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