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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 45, Iss. 30 — Oct. 20, 2006
  • pp: 7938–7943

Intravascular Raman spectroscopic catheter for molecular diagnosis of atherosclerotic coronary disease

Yuichi Komachi, Hidetoshi Sato, and Hideo Tashiro  »View Author Affiliations


Applied Optics, Vol. 45, Issue 30, pp. 7938-7943 (2006)
http://dx.doi.org/10.1364/AO.45.007938


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Abstract

An intravascular catheter for Raman spectroscopic detection and analysis of coronary atherosclerotic disease has been developed. The catheter, having an outer diameter of 2 mm, consisted of a side-view-type micro-Raman probe, an imaging fiber bundle, a working channel (injection drain), and a balloon. By inflating the balloon, the probe was brought close to the inner wall of a modeled blood flow system and detected a phantom target buried in the wall. Results obtained demonstrate the possibility of using the spectroscopic catheter for molecular diagnosis of coronary lesions.

© 2006 Optical Society of America

OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.5660) Medical optics and biotechnology : Raman spectroscopy

History
Original Manuscript: January 30, 2006
Revised Manuscript: May 30, 2006
Manuscript Accepted: June 18, 2006

Virtual Issues
Vol. 1, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Yuichi Komachi, Hidetoshi Sato, and Hideo Tashiro, "Intravascular Raman spectroscopic catheter for molecular diagnosis of atherosclerotic coronary disease," Appl. Opt. 45, 7938-7943 (2006)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-45-30-7938


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