Intravascular Raman spectroscopic catheter for molecular diagnosis of atherosclerotic coronary disease
Applied Optics, Vol. 45, Issue 30, pp. 7938-7943 (2006)
http://dx.doi.org/10.1364/AO.45.007938
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Abstract
An intravascular catheter for Raman spectroscopic detection and analysis of coronary atherosclerotic disease has been developed. The catheter, having an outer diameter of 2 mm, consisted of a side-view-type micro-Raman probe, an imaging fiber bundle, a working channel (injection drain), and a balloon. By inflating the balloon, the probe was brought close to the inner wall of a modeled blood flow system and detected a phantom target buried in the wall. Results obtained demonstrate the possibility of using the spectroscopic catheter for molecular diagnosis of coronary lesions.
© 2006 Optical Society of America
OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.5660) Medical optics and biotechnology : Raman spectroscopy
History
Original Manuscript: January 30, 2006
Revised Manuscript: May 30, 2006
Manuscript Accepted: June 18, 2006
Virtual Issues
Vol. 1, Iss. 11 Virtual Journal for Biomedical Optics
Citation
Yuichi Komachi, Hidetoshi Sato, and Hideo Tashiro, "Intravascular Raman spectroscopic catheter for molecular diagnosis of atherosclerotic coronary disease," Appl. Opt. 45, 7938-7943 (2006)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-45-30-7938
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