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Applied Optics

Applied Optics


  • Editor: James C. Wyant
  • Vol. 45, Iss. 36 — Dec. 20, 2006
  • pp: 9230–9237

Pulsed quantum cascade laser-based cavity ring-down spectroscopy for ammonia detection in breath

Jagadeeshwari Manne, Oleksandr Sukhorukov, Wolfgang Jäger, and John Tulip  »View Author Affiliations

Applied Optics, Vol. 45, Issue 36, pp. 9230-9237 (2006)

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Breath analysis can be a valuable, noninvasive tool for the clinical diagnosis of a number of pathological conditions. The detection of ammonia in exhaled breath is of particular interest for it has been linked to kidney malfunction and peptic ulcers. Pulsed cavity ringdown spectroscopy in the mid-IR region has developed into a sensitive analytical technique for trace gas analysis. A gas analyzer based on a pulsed mid-IR quantum cascade laser operating near 970 cm 1 has been developed for the detection of ammonia levels in breath. We report a sensitivity of 50 parts per billion with a 20 s time resolution for ammonia detection in breath with this system. The challenges and possible solutions for the quantification of ammonia in human breath by the described technique are discussed.

© 2006 Optical Society of America

OCIS Codes
(140.5960) Lasers and laser optics : Semiconductor lasers
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(280.3420) Remote sensing and sensors : Laser sensors
(300.1030) Spectroscopy : Absorption
(300.6340) Spectroscopy : Spectroscopy, infrared

Original Manuscript: April 4, 2006
Revised Manuscript: August 16, 2006
Manuscript Accepted: September 1, 2006

Virtual Issues
Vol. 2, Iss. 1 Virtual Journal for Biomedical Optics

Jagadeeshwari Manne, Oleksandr Sukhorukov, Wolfgang Jäger, and John Tulip, "Pulsed quantum cascade laser-based cavity ring-down spectroscopy for ammonia detection in breath," Appl. Opt. 45, 9230-9237 (2006)

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