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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 45, Iss. 5 — Feb. 10, 2006
  • pp: 1062–1071

Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms

Gregory M. Palmer and Nirmala Ramanujam  »View Author Affiliations


Applied Optics, Vol. 45, Issue 5, pp. 1062-1071 (2006)
http://dx.doi.org/10.1364/AO.45.001062


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Abstract

A flexible and fast Monte Carlo-based model of diffuse reflectance has been developed for the extraction of the absorption and scattering properties of turbid media, such as human tissues. This method is valid for a wide range of optical properties and is easily adaptable to existing probe geometries, provided a single phantom calibration measurement is made. A condensed Monte Carlo method was used to speed up the forward simulations. This model was validated by use of two sets of liquid-tissue phantoms containing Nigrosin or hemoglobin as absorbers and polystyrene spheres as scatterers. The phantoms had a wide range of absorption ( 0 20 cm 1 ) and reduced scattering coefficients ( 7 33 cm 1 ) . Mie theory and a spectrophotometer were used to determine the absorption and reduced scattering coefficients of the phantoms. The diffuse reflectance spectra of the phantoms were measured over a wavelength range of 350 8 5 0   nm . It was found that optical properties could be extracted from the experimentally measured diffuse reflectance spectra with an average error of 3 % or less for phantoms containing hemoglobin and 12 % or less for phantoms containing Nigrosin.

© 2006 Optical Society of America

OCIS Codes
(160.4760) Materials : Optical properties
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 5, 2004
Revised Manuscript: March 29, 2005
Manuscript Accepted: May 8, 2005

Virtual Issues
Vol. 1, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Gregory M. Palmer and Nirmala Ramanujam, "Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms," Appl. Opt. 45, 1062-1071 (2006)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-45-5-1062

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