OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 45, Iss. 9 — Mar. 20, 2006
  • pp: 2101–2114

Information content of point radiance measurements in turbid media: implications for interstitial optical property quantification

Lee C. L. Chin, William M. Whelan, and I. Alex Vitkin  »View Author Affiliations


Applied Optics, Vol. 45, Issue 9, pp. 2101-2114 (2006)
http://dx.doi.org/10.1364/AO.45.002101


View Full Text Article

Acrobat PDF (425 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Motivated by a recent report by Dickey et al. [Phys. Med. Biol. 46, 2359 (2001)], who demonstrated optical property retrieval by using relative radiance measurements at a single position, we investigate the uniqueness of relative radiance measurements for quantifying the optical properties of turbid media by studying the solutions of the diffusion and P3 approximations of the Boltzmann transfer equation for a point source. Using the P3 approximation, we investigate the potential of radiance measurements for optical property recovery by examining the optical property response surface for point radiance information. We further derive first-order similarity relations for relative point radiance measurements and use these expressions to examine analytically the effects of noise on optical property retrieval over a wide range of optical properties typical of biological tissue. Finally, optimal experimental configurations are studied and explicit conditions for uniqueness derived that suggest potential strategies for improving optical property recovery. It is expected that point radiance measurements will prove valuable for both on-line treatment planning of minimally invasive laser therapies and optical characterization of tissues.

© 2006 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.7050) Medical optics and biotechnology : Turbid media
(290.1990) Scattering : Diffusion
(290.4210) Scattering : Multiple scattering

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 10, 2005
Revised Manuscript: September 17, 2005
Manuscript Accepted: September 20, 2005

Virtual Issues
Vol. 1, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Lee C. L. Chin, William M. Whelan, and I. Alex Vitkin, "Information content of point radiance measurements in turbid media: implications for interstitial optical property quantification," Appl. Opt. 45, 2101-2114 (2006)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-45-9-2101


Sort:  Author  |  Journal  |  Reset

References

  1. D. R. Wyman, M. S. Patterson, and B. C. Wilson, "Similarity relations for the interaction parameters in radiation transport," Appl. Opt. 28, 5243-5249 (1989).
  2. L. Lilge, N. Pomerleau-Dalcourt, A. Douplik, S. H. Selman, R. W. Keck, M. Szkudlarek, M. Pestka, and J. Jankun, "Transperineal in vivo fluence-rate dosimetry in the canine prostate during SnET2-mediated PDT," Phys. Med. Biol. 49, 3209-3225 (2004).
  3. T. C. Zhu, A. Dimofte, J. C. Finlay, D. Stripp, T. Busch, J. Miles, R. Whittington, S. B. Malkowicz, Z. Tochner, E. Glatstein, and S. M. Hahn, "Optical properties of human prostate at 732 nm measured in vivo during motexafin lutetium-mediated photodynamic therapy," Photochem. Photobiol. 81, 96-105 (2005).
  4. O. Bajaras, A. M. Ballangrud, G. G. Miller, R. B. Moore, and J. Tulip, "Monte Carlo modeling of angular radiance in tissue phantoms and human prostate: PDT light dosimetry," Phys. Med. Biol. 42, 1675-1687 (1997).
  5. L. C. L. Chin, B. C. Wilson, W. M. Whelan, and I. A. Vitkin, "Radiance-based monitoring of the coagulation boundary during laser interstitial thermal therapy," Opt. Lett. 29, 959-961 (2004).
  6. D. J. Dickey, R. B. Moore, D. C. Rayner, and J. Tulip, "Light dosimetry using the P3 approximation," Phys. Med. Biol. 46, 2359-2370 (2001).
  7. L. G. Henyey and J. L. Greenstein, "Diffuse radiation in the galaxy," Astrophys. J. 93, 70-83 (1941).
  8. J. C. Finlay and T. H. Foster, "Hemoglobin oxygen saturations in phantoms and in vivo from measurements of steady-state diffuse reflectance at a single, short source-detector separation," Med. Phys. 31, 1949-1959 (2004).
  9. K. M. Case and P. F. Zweifel, Linear Transport Theory (Addison-Wesley, 1967).
  10. E. L. Hull, and T. H. Foster, "Steady-state reflectance spectroscopy in the P3 approximation," J. Opt. Soc. Am. A 18, 584-599 (2001).
  11. D. A. Boas, "Diffuse photon probes of structural and dynamical properties of turbid media: theory and biomedical applications," Ph.D. dissertation (University of Pennylvania, 1996).
  12. F. Martelli, M. Bassani, L. Alianelli, L. Zangheri, and G. Zaccanti, "Accuracy of the diffusion equation to describe photon migration through an infinite medium: numerical and experimental investigation," Phys. Med. Biol. 45, 1359-1373 (2000).
  13. J. P. Marijnissen and W. M. Star, "Calibration of isotropic light dosimetry probes based on scattering bulbs in clear media," Phys. Med. Biol. 41, 1191-1208 (1996).
  14. J. P. Marijnissen and W. M. Star, "Performance of isotropic light dosimetry probes based on scattering bulbs in turbid media," Phys. Med. Biol. 47, 2049-2058 (2002).
  15. L. H. Wang, S. L. Jacques, and L. Zheng, "MCML--Monte Carlo modeling of light transport in multilayered tissues," Comput. Methods Programs Biomed. 47, 131-146 (1995).
  16. L. Chin, M. Pop, W. Whelan, M. Sherar, and A. Vitkin, "Optical method using fluence or radiance measurements to monitor thermal therapy," Rev. Sci. Instrum. 74, 393-395 (2003).
  17. F. Bevilacqua and C. Depeursinge, "Monte Carlo study of diffuse reflectance at source-detector separations close to one transport mean free path," J. Opt. Soc. Am. A 16, 2935-2945 (1999).
  18. W. W. Whelan, P. Chun, L. C. Chin, M. D. Sherar, and I. A. Vitkin, "Laser thermal therapy: utility of interstitial fluence monitoring for locating optical sensors," Phys. Med. Biol. 46, N91-N96 (2001).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited