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Applied Optics

Applied Optics


  • Editor: James C. Wyant
  • Vol. 46, Iss. 10 — Apr. 1, 2007
  • pp: 1615–1623

Ultrasound-modulated optical tomography with intense acoustic bursts

Roger J. Zemp, Chulhong Kim, and Lihong V. Wang  »View Author Affiliations

Applied Optics, Vol. 46, Issue 10, pp. 1615-1623 (2007)

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Ultrasound-modulated optical tomography (UOT) detects ultrasonically modulated light to spatially localize multiply scattered photons in turbid media with the ultimate goal of imaging the optical properties in living subjects. A principal challenge of the technique is weak modulated signal strength. We discuss ways to push the limits of signal enhancement with intense acoustic bursts while conforming to optical and ultrasonic safety standards. A CCD-based speckle-contrast detection scheme is used to detect acoustically modulated light by measuring changes in speckle statistics between ultrasound-on and ultrasound-off states. The CCD image capture is synchronized with the ultrasound burst pulse sequence. Transient acoustic radiation force, a consequence of bursts, is seen to produce slight signal enhancement over pure ultrasonic-modulation mechanisms for bursts and CCD exposure times of the order of milliseconds. However, acoustic radiation-force-induced shear waves are launched away from the acoustic sample volume, which degrade UOT spatial resolution. By time gating the CCD camera to capture modulated light before radiation force has an opportunity to accumulate significant tissue displacement, we reduce the effects of shear-wave image degradation, while enabling very high signal-to-noise ratios. Additionally, we maintain high-resolution images representative of optical and not mechanical contrast. Signal-to-noise levels are sufficiently high so as to enable acquisition of 2D images of phantoms with one acoustic burst per pixel.

© 2007 Optical Society of America

OCIS Codes
(110.6150) Imaging systems : Speckle imaging
(110.6960) Imaging systems : Tomography
(110.7050) Imaging systems : Turbid media
(110.7170) Imaging systems : Ultrasound
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Diffuse optical imaging

Original Manuscript: June 12, 2006
Revised Manuscript: October 4, 2006
Manuscript Accepted: October 10, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Roger J. Zemp, Chulhong Kim, and Lihong V. Wang, "Ultrasound-modulated optical tomography with intense acoustic bursts," Appl. Opt. 46, 1615-1623 (2007)

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