We study the effect of tissue anisotropy in optical tomography of neonates. A Monte Carlo method capable of modeling photon migration in an arbitrary 3D tissue model with spatially varying optical properties and tissue anisotropy is used for simulating measurements of neonates. Anatomical and diffusion tensor magnetic resonance imaging of neonates are used for creating the anatomical models. We find that tissue anisotropy affects the measured signal and the pattern of sensitivity in optical measurements.
© 2007 Optical Society of America
Diffuse optical imaging
Original Manuscript: July 3, 2006
Manuscript Accepted: August 10, 2006
Published: March 13, 2007
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics
Juha Heiskala, Tuomas Neuvonen, P. Ellen Grant, and Ilkka Nissilä, "Significance of tissue anisotropy in optical tomography of the infant brain," Appl. Opt. 46, 1633-1640 (2007)