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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 10 — Apr. 1, 2007
  • pp: 1679–1685

Optimal sparse solution for fluorescent diffuse optical tomography: theory and phantom experimental results

Pouyan Mohajerani, Ali A. Eftekhar, Jiandong Huang, and Ali Adibi  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1679-1685 (2007)
http://dx.doi.org/10.1364/AO.46.001679


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Abstract

We present a method to accurately localize small fluorescent objects within the tissue using fluorescent diffuse optical tomography (FDOT). The proposed method exploits the localized or sparse nature of the fluorophores in the tissue as a priori information to considerably improve the accuracy of the reconstruction of fluorophore distribution. This is accomplished by minimizing a cost function that includes the L 1 norm of the fluorophore distribution vector. Experimental results for a milk-based phantom using a fiber-based cw FDOT system demonstrate the capability of this method in accurately localizing small fluorescent objects deep in the phantom.

© 2007 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Diffuse optical imaging

History
Original Manuscript: July 5, 2006
Revised Manuscript: November 30, 2006
Manuscript Accepted: December 1, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Pouyan Mohajerani, Ali A. Eftekhar, Jiandong Huang, and Ali Adibi, "Optimal sparse solution for fluorescent diffuse optical tomography: theory and phantom experimental results," Appl. Opt. 46, 1679-1685 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-10-1679

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