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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 10 — Apr. 1, 2007
  • pp: 1686–1692

Comparison of simplified Monte Carlo simulation and diffusion approximation for the fluorescence signal from phantoms with typical mouse tissue optical properties

Guobin Ma, Jean-François Delorme, Pascal Gallant, and David A. Boas  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1686-1692 (2007)
http://dx.doi.org/10.1364/AO.46.001686


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Abstract

A simplified approach is proposed to simulate the fluorescence signal from a fluorophore submerged inside a turbid medium using the Monte Carlo method. Based on the reversibility of photon propagation, the fluorescence signal can be obtained from a single Monte Carlo simulation of the excitation light. This is computationally less expensive and also allows for the direct use of well-validated nonfluorescence photon migration Monte Carlo codes. Fluorescence signals from a mouse tissuelike phantom were computed using both the simplified Monte Carlo simulation and the diffusion approximation. The relative difference of signal intensity was found to be at most 30% for a fluorophore placed in the medium at various depths and horizontally midway between a source–detector pair separated by 3   mm . The difference in time characteristics of the signal is also examined.

© 2007 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5280) Medical optics and biotechnology : Photon migration
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.7050) Medical optics and biotechnology : Turbid media
(290.1990) Scattering : Diffusion

ToC Category:
Diffuse optical imaging

History
Original Manuscript: July 5, 2006
Revised Manuscript: November 20, 2006
Manuscript Accepted: December 1, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Guobin Ma, Jean-François Delorme, Pascal Gallant, and David A. Boas, "Comparison of simplified Monte Carlo simulation and diffusion approximation for the fluorescence signal from phantoms with typical mouse tissue optical properties," Appl. Opt. 46, 1686-1692 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-10-1686


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