Polarization effects on scatterer sizing accuracy analyzed with frequency-domain angle-resolved low-coherence interferometry
Applied Optics, Vol. 46, Issue 10, pp. 1735-1741 (2007)
http://dx.doi.org/10.1364/AO.46.001735
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Abstract
Angle-resolved low-coherence interferometry (a∕LCI) enables us to make depth-resolved measurements of scattered light that can be used to recover subsurface structural information such as the size of cell nuclei. Endoscopic frequency-domain a∕LCI (fa∕LCI) acquires data by using a novel fiber probe in a fraction of a second, making it a clinically practical system. However, birefringent effects in fiber-based systems can alter the polarization state of the incident light and potentially skew the collected data. We analyze the effect the polarization state of the incident light has on scattering data collected from polystyrene microsphere tissue phantoms and in vitro cell samples and examine the subsequent accuracy of the determined sizes. It is shown that the endoscopic fa∕LCI system accurately determines the size of polystyrene microspheres without the need to control the polarization of the incident beam, but that epithelial cell nuclear sizes are accurately determined only when the polarization state of the incident light is well characterized.
© 2007 Optical Society of America
OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
ToC Category:
Optical spectroscopic imaging and diagnostics
History
Original Manuscript: June 22, 2006
Revised Manuscript: September 22, 2006
Manuscript Accepted: September 29, 2006
Published: March 13, 2007
Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics
Citation
John W. Pyhtila and Adam Wax, "Polarization effects on scatterer sizing accuracy analyzed with frequency-domain angle-resolved low-coherence interferometry," Appl. Opt. 46, 1735-1741 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-10-1735
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