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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 10 — Apr. 1, 2007
  • pp: 1866–1871

Recording invertebrate nerve activation with modulated light changes

Matthew D. McCluskey, Jeffrey J. Sable, Amanda J. Foust, Gabriele Gratton, and David M. Rector  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1866-1871 (2007)
http://dx.doi.org/10.1364/AO.46.001866


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Abstract

Optical scattering techniques have the potential to provide noninvasive measurements of neural activity with good spatial and temporal resolution. We used the lobster nerve as a model system to investigate and record event-related optical signals with a modulated light source and heterodyne detection system. We observed changes in the transmitted birefringent light intensity, corresponding with electrophysiological measurements of the action potential. The photon delay was below the detection threshold, in part due to the small size of the nerve bundle. Our system allowed us to place an upper bound on the magnitude of the phase change of 0.01°. The physiological stability of the preparation allows comprehensive characterization of biological and instrumentation noise sources for testing optical measurement systems.

© 2007 Optical Society of America

OCIS Codes
(170.5280) Medical optics and biotechnology : Photon migration
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Optics in neuroscience

History
Original Manuscript: June 29, 2006
Revised Manuscript: October 23, 2006
Manuscript Accepted: November 16, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Matthew D. McCluskey, Jeffrey J. Sable, Amanda J. Foust, Gabriele Gratton, and David M. Rector, "Recording invertebrate nerve activation with modulated light changes," Appl. Opt. 46, 1866-1871 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-10-1866


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