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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 10 — Apr. 1, 2007
  • pp: 1911–1917

Monitoring thermal-induced changes in tumor blood flow and microvessels with laser speckle contrast imaging

Dan Zhu, Wei Lu, Yang Weng, Han Cui, and Qingming Luo  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1911-1917 (2007)
http://dx.doi.org/10.1364/AO.46.001911


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Abstract

Laser speckle contrast imaging (LSCI) was used to monitor thermal-induced changes in the blood flow and the diameter of mesenteric microvessels of normal and tumor bearing mice under 60 min treatment at different constant temperatures between 41 ° C   and   45   ° C . The results show that the blood flow and the diameter increase at the beginning and then reach a plateau and finally start to decrease. The lower the temperature, the longer the plateau stays. A t-test indicates that there is no significant difference in plateau values of relative blood flow and relative diameter for the same group. For normal mice, the relative increases in the blood flow and the diameter are 1.26 and 1.41, respectively, while for tumor-bearing mice they are 1.08 and 1.13, respectively. At higher treatment temperature or under longer heat treatment, there are decreases in the blood flow and the diameter, such changes in tumor-bearing mice are more obvious than those in normal mice, which means tumor microvessels are more sensitive to heat than normal. Moreover, thermal induced shrink of microvessel usually occurs sooner than the decrease in blood flow, and the relative change in diameter is larger than that in blood flow. Therefore we may conclude that deformation of vessel is a main factor for changing the blood perfusion of a microvessel.

© 2007 Optical Society of America

OCIS Codes
(120.6150) Instrumentation, measurement, and metrology : Speckle imaging
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle
(280.2490) Remote sensing and sensors : Flow diagnostics

ToC Category:
Optics in cancer research

History
Original Manuscript: July 3, 2006
Revised Manuscript: December 13, 2006
Manuscript Accepted: December 29, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Dan Zhu, Wei Lu, Yang Weng, Han Cui, and Qingming Luo, "Monitoring thermal-induced changes in tumor blood flow and microvessels with laser speckle contrast imaging," Appl. Opt. 46, 1911-1917 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-10-1911

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