OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 10 — Apr. 1, 2007
  • pp: 1911–1917

Monitoring thermal-induced changes in tumor blood flow and microvessels with laser speckle contrast imaging

Dan Zhu, Wei Lu, Yang Weng, Han Cui, and Qingming Luo  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1911-1917 (2007)
http://dx.doi.org/10.1364/AO.46.001911


View Full Text Article

Enhanced HTML    Acrobat PDF (1120 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Laser speckle contrast imaging (LSCI) was used to monitor thermal-induced changes in the blood flow and the diameter of mesenteric microvessels of normal and tumor bearing mice under 60 min treatment at different constant temperatures between 41 ° C   and   45   ° C . The results show that the blood flow and the diameter increase at the beginning and then reach a plateau and finally start to decrease. The lower the temperature, the longer the plateau stays. A t-test indicates that there is no significant difference in plateau values of relative blood flow and relative diameter for the same group. For normal mice, the relative increases in the blood flow and the diameter are 1.26 and 1.41, respectively, while for tumor-bearing mice they are 1.08 and 1.13, respectively. At higher treatment temperature or under longer heat treatment, there are decreases in the blood flow and the diameter, such changes in tumor-bearing mice are more obvious than those in normal mice, which means tumor microvessels are more sensitive to heat than normal. Moreover, thermal induced shrink of microvessel usually occurs sooner than the decrease in blood flow, and the relative change in diameter is larger than that in blood flow. Therefore we may conclude that deformation of vessel is a main factor for changing the blood perfusion of a microvessel.

© 2007 Optical Society of America

OCIS Codes
(120.6150) Instrumentation, measurement, and metrology : Speckle imaging
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle
(280.2490) Remote sensing and sensors : Flow diagnostics

ToC Category:
Optics in cancer research

History
Original Manuscript: July 3, 2006
Revised Manuscript: December 13, 2006
Manuscript Accepted: December 29, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Dan Zhu, Wei Lu, Yang Weng, Han Cui, and Qingming Luo, "Monitoring thermal-induced changes in tumor blood flow and microvessels with laser speckle contrast imaging," Appl. Opt. 46, 1911-1917 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-10-1911


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. M. Falk, R. Issels. "Hyperthermia in oncology," Int. J. Hyperthermia 17, 1-18 (2001). [CrossRef] [PubMed]
  2. J. W. Valvano, "Tissue thermal properties and perfusion," in Optical Thermal Response of Laser-Irradiated Tissue, A. J. Welch and M. J. C. van Germert, eds. (Plenum, 1995), pp. 469-478.
  3. H. P. Kok, P. M. A. van Haaren, J. D. P. van Dijk, and J. Crezee, "On estimation of the temperature maximum in intraluminal or intracavitary hyperthermia," Int. J. Hyperthermia 21, 287-304 (2005). [CrossRef] [PubMed]
  4. B. M. Kim, S. L. Jacques, S. Rastegar, S. Thomsen, and M. Motamedi, "Nonlinear finite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue," IEEE J. Sel. Top. Quantum Electron. 2, 922-33 (1996). [CrossRef]
  5. B. S. Naii, I. B. Choi, W. Y. Oh, J. L. Osborn, and C. W. Song, "Vascular thermal adaptation in tumors and normal tissue in rats," Int. J. Radiat. Oncol. Biol. Phys. 35, 95-101 (1996).
  6. S. L. Bacharach, S. K. Libutti, and J. A. Carrasquillo, "Measuring tumor blood flow with H215O: practical considerations," Nucl. Med. Biol. 27, 671-676 (2000). [CrossRef] [PubMed]
  7. C. Sturesson, K. Ivarsson, S. Andersson-Engels, and K.-G. Tranberg, "Changes in local hepatic blood perfusion during interstitial laser-induced thermotherapy of normal rat liver measured by interstitial laser Doppler flowmetry," Lasers Med. Sci. 14, 143-149 (1999). [CrossRef]
  8. I. V. Sils, P. C. Szlyk-Modrow, K. A. Tartarini, C. B. Matthew, and R. P. Francesconi, "Effect of nitric oxide synthase inhibition on regional blood flow during hyperthermia," J. Thermal Bio. 26, 1-7 (2001). [CrossRef]
  9. E. J. Droog, W. Steenbergen, and F. Sjoberg, "Measurement of depth of burns by laser Doppler perfusion imaging," Burns 27, 561-68 (2001). [CrossRef] [PubMed]
  10. J. Liu and L. X. Xu, "Boundary information-based diagnostics on the thermal states of biological bodies," Int. J. Heat Mass Transfer 43, 2827-2839 (2000). [CrossRef]
  11. J. Liu and L. X. Xu, "Estimation of blood perfusion using phase shift in temperature response to sinusoidal heat at the skin surface," IEEE Trans. Biomed. Eng. 46, 1037-1043 (1999). [CrossRef] [PubMed]
  12. S. R. Paul, P. S. Elaine, and E. T. Diller, "Validation of methodologies for the estimation of blood perfusion using a minimally invasive probe," ASME J. Heat Transfer 362, 109-116 (1998).
  13. J. D. Briers, G. Richards, and X. W. He, "Capillary blood flow monitoring using laser speckle contrast analysis (LASCA)," J. Biomed. Opt. 4, 164-175 (1999). [CrossRef]
  14. J. D. Briers and S. Webster, "Laser speckle contrast analysis (LASCA): a nonscanning, full-field technique for monitoring capillary blood flow," J. Biomed. Opt. 1, 174-179 (1996). [CrossRef]
  15. H. Cheng, Q. Luo, Z. Wang, H. Gong, S. Chen, W. Liang, and S. Zeng, "Efficient characterization of regional mesenteric blood flow by use of laser speckle imaging," Appl. Opt. 42, 5759-5764 (2003). [CrossRef] [PubMed]
  16. H. Cheng, Q. Luo, S. Zeng, S. Chen, W. Luo, and H. Gong, "Hyperosmotic chemical agent's effect on in vivo cerebral blood flow revealed by laser speckle," Appl. Opt. 43, 5772-5777 (2004). [CrossRef] [PubMed]
  17. H. Cheng, Q. Luo, Q. Liu, Q. Lu, H. Gong, and S. Zeng, "Laser speckle imaging of blood flow in microcirculation," Phys. Med. Biol. 49, 1347-1357 (2004). [CrossRef] [PubMed]
  18. S. Yuan, A. Devor, D. A. Boas, and A. K. Dunn, "Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging," Appl. Opt. 44, 1823-1830 (2005). [CrossRef] [PubMed]
  19. A. F. Fercher and J. D. Briers, "Flow visualization by means of single-exposure speckle photography," Opt. Commun. 37, 326-329 (1981). [CrossRef]
  20. C. Cheng, C. Liu, N. Zhang, T. Jia, R. Li, and Z. Xu, "Absolute measurement of roughness and lateral-correlation length of random surfaces by use of the simplified model of image-speckle contrast," Appl. Opt. 41, 4148-4156 (2002). [CrossRef] [PubMed]
  21. H. T. Yura and S. G. Hanson, "Comment: absolute measurement of roughness and lateral-correlation length of random surfaces by use of the simplified model of image-speckle contrast," Appl. Opt. 42, 2521-2522 (2003). [CrossRef] [PubMed]
  22. C. Cheng, C. Liu, N. Zhang, T. Jia, R. Li, and Z. Xu, "Reply to comment: absolute measurement of roughness and lateral-correlation length of random surfaces by use of the simplified model of image-speckle contrast," Appl. Opt. 42, 2523-2525 (2003). [CrossRef]
  23. S. L. Brown and J. W. Hunt, "Different thermal sensitivity of tumor and normal tissue microvascular response during hyperthermia," Int. J. Hyperthermia 8, 501-514 (1992). [CrossRef] [PubMed]
  24. J. C. Lin and C. W. Song, "Influence of vascular thermotolerance on the heat-induced changes in blood flow, pO2, and cell survival in tumor," Cancer Res. 53, 2076-2080 (1993). [PubMed]
  25. B. Hildebrandt, P. Wust, and O. Ahlers, "The cellular and molecular basis of hyperthermia," Crit. Rev. Oncol. Hemat. 13, 33-56 (2002). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 
Fig. 4
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited