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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 13 — May. 1, 2007
  • pp: 2520–2527

Polarization-sensitive optical coherence tomography for imaging human atherosclerosis

Wen-Chuan Kuo, Nai-Kuan Chou, Chien Chou, Chih-Ming Lai, Huan-Jang Huang, Shoei-Shen Wang, and Jeou-Jong Shyu  »View Author Affiliations


Applied Optics, Vol. 46, Issue 13, pp. 2520-2527 (2007)
http://dx.doi.org/10.1364/AO.46.002520


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Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) combines the advantages of OCT with image contrast enhancement, which is based on its ability to detect phase retardation and the fast-axis angle. Both PS-OCT images and histopathology have demonstrated similar features that allowed differentiation of atherosclerotic structures (i.e., plaques) from normal tissue. Moreover, the picrosirius polarization method was used to confirm PS-OCT assessment of collagen in the fibrous cap of atherosclerotic plaques, and high-frequency (40 MHz) ultrasound images were used to identify calcium in the vessel wall. Our preliminary ex vivo investigation of human aortic specimens indicated that PS-OCT might help to identify atherosclerotic lesions.

© 2007 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(260.5430) Physical optics : Polarization

ToC Category:
Imaging Systems

History
Original Manuscript: October 3, 2006
Manuscript Accepted: November 16, 2006
Published: April 9, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Wen-Chuan Kuo, Nai-Kuan Chou, Chien Chou, Chih-Ming Lai, Huan-Jang Huang, Shoei-Shen Wang, and Jeou-Jong Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt. 46, 2520-2527 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-13-2520

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