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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 16 — Jun. 1, 2007
  • pp: 3359–3368

Feasibility analysis of an epidermal glucose sensor based on time-resolved fluorescence

Kamal M. Katika and Laurent Pilon  »View Author Affiliations


Applied Optics, Vol. 46, Issue 16, pp. 3359-3368 (2007)
http://dx.doi.org/10.1364/AO.46.003359


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Abstract

The goal of this study is to test the feasibility of using an embedded time-resolved fluorescence sensor for monitoring glucose concentration. Skin is modeled as a multilayer medium with each layer having its own optical properties and fluorophore absorption coefficients, lifetimes, and quantum yields obtained from the literature. It is assumed that the two main fluorophores contributing to the fluorescence at these excitation and emission wavelengths are nicotinamide adenine dinucleotide (NAD)H and collagen. The intensity distributions of excitation and fluorescent light in skin are determined by solving the transient radiative transfer equation by using the modified method of characteristics. The fluorophore lifetimes are then recovered from the simulated fluorescence decays and compared with the actual lifetimes used in the simulations. Furthermore, the effect of adding Poissonian noise to the simulated decays on recovering the lifetimes was studied. For all cases, it was found that the fluorescence lifetime of NADH could not be recovered because of its negligible contribution to the overall fluorescence signal. The other lifetimes could be recovered to within 1.3% of input values. Finally, the glucose concentrations within the skin were recovered to within 13.5% of their actual values, indicating a possibility of measuring glucose concentrations by using a time-resolved fluorescence sensor.

© 2007 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3650) Medical optics and biotechnology : Lifetime-based sensing
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(260.2510) Physical optics : Fluorescence

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 13, 2006
Revised Manuscript: February 9, 2007
Manuscript Accepted: February 13, 2007
Published: May 15, 2007

Virtual Issues
Vol. 2, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Kamal M. Katika and Laurent Pilon, "Feasibility analysis of an epidermal glucose sensor based on time-resolved fluorescence," Appl. Opt. 46, 3359-3368 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-16-3359


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References

  1. J. Pickup, F. Hussain, N. Evans, and N. Sachedina, "In vivo glucose monitoring: the clinical reality and the promise," Biosens. Bioelectron. 20, 1897-902 (2005). [CrossRef] [PubMed]
  2. R. Richards-Kortum and E. Sevick-Muraca, "Quantitative optical spectroscopy for tissue diagnostics," Ann. Rev. Phys. Chem. 47, 555-606 (1996). [CrossRef]
  3. M. McShane, S. Rastegar, and G. Cote, "Fluorescence-based implantable biosensors: Monte Carlo modeling for optical probe design," Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE, 1998), Vol. 4, pp. 1799-1802.
  4. M. McShane, S. Rastegar, M. Pishko, and G. Cote, "Monte Carlo modeling for implantable fluorescent analyte sensors," IEEE Trans. Biomed. Eng. 47, 624-632 (2000). [CrossRef] [PubMed]
  5. D. P. O'Neal, M. J. McShane, M. V. Pishko, and G. L. Cote, "Implantable biosensors: analysis of fluorescent light propagation through skin," Proc. SPIE 4263, 20-24 (2001). [CrossRef]
  6. N. DiCesare and J. R. Lakowicz, "Evaluation of two synthetic glucose probes for fluorescence-lifetime-based sensing," Anal. Biochem. 294, 154-160 (2001). [CrossRef] [PubMed]
  7. J. R. Lakowicz, Principles of Fluorescence Spectroscopy (Kluwer Academic/Plenum, 1999).
  8. M. Keijzer, R. Richards-Kortum, S. Jacques, and M. Feld, "Fluorescence spectroscopy of turbid media: autofluorescence of the human aorta," Appl. Opt. 28, 4286-4292 (1989). [CrossRef] [PubMed]
  9. I. V. Meglinski and D. Y. Churmakov, "A novel Monte Carlo method for the optical diagnostics of skin," Proc. SPIE 5141, 133-141 (2003). [CrossRef]
  10. I. V. Meglinski, "Monte Carlo method in optical diagnostics of skin and skin tissues," Proc. SPIE 5254, 30-43 (2003). [CrossRef]
  11. H. Zeng, C. E. MacAulay, B. Palcic, and D. I. McLean, "Monte Carlo modeling of tissue autofluorescence measurement and imaging," Proc. SPIE 2135, 94-104 (1994). [CrossRef]
  12. K. Vishwanath, B. Pogue, and M.-A. Mycek, "Quantitative fluorescence lifetime spectroscopy in turbid media: comparison of theoretical, experimental and computational methods," Phys. Med. Biol. 47, 3387-3405 (2002). [CrossRef] [PubMed]
  13. M.-A. Mycek, K. Vishwanath, B. W. Pogue, K. T. Schomacker, and N. S. Nishioka, "Simulations of time-resolved fluorescence in multilayered biological tissues: applications to clinical data modeling," Proc. SPIE 4958, 51-59 (2003). [CrossRef]
  14. K. Vishwanath and M.-A. Mycek, "Do fluorescence decays remitted from tissues accurately reflect intrinsic fluorophore lifetimes?" Opt. Lett. 29, 1512-1514 (2004). [CrossRef] [PubMed]
  15. M. S. Patterson and B. W. Pogue, "Mathematical model for time-resolved and frequency-domain fluorescence spectroscopy in biological tissues," Appl. Opt. 33, 1963-1974 (1994). [CrossRef] [PubMed]
  16. M. A. O'Leary, D. A. Boas, X. D. Li, B. Chance, and A. G. Yodh, "Fluorescence lifetime imaging in turbid media," Opt. Lett. 21, 158-160 (1996). [CrossRef] [PubMed]
  17. E. M. Sevick-Muraca and D. Y. Paithankar, "Imaging of fluorescence yield and lifetime from multiply scattered light re-emitted from random media," Proc. SPIE 2980, 303-318 (1997).
  18. D. Y. Paithankar, A. U. Chen, B. W. Pogue, M. S. Patterson, and E. M. Sevick-Muraca, "Imaging of fluorescent yield and lifetime from multiply scattered light reemitted from random media," Appl. Opt. 36, 2260-2272 (1997). [CrossRef] [PubMed]
  19. A. H. Hielscher, R. E. Alcouffe, and R. L. Barbour, "Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues," Phys. Med. Biol. 43, 1285-1302 (1998). [CrossRef] [PubMed]
  20. B. Chen, K. Stamnes, and J. J. Stamnes, "Validity of the diffusion approximation in bio-optical imaging," Appl. Opt. 40, 6536-6366 (2001). [CrossRef]
  21. H. Zeng, C. MacAulay, D. I. McLean, and B. Palcic, "Reconstruction of in vivo skin autofluorescence spectrum from microscopic properties by Monte Carlo simulation," J. Photochem. Photobiol. B 38, 234-240 (1997). [CrossRef] [PubMed]
  22. R. Gillies, G. Zonios, R. R. Anderson, and N. Kollias, "Fluorescence excitation spectroscopy provides information about human skin in vivo," J. Investig. Dermatol. 115, 704-707 (2000). [CrossRef] [PubMed]
  23. K. Katika and L. Pilon, "Modified method of characteristics in transient radiative transfer," J. Quant. Spectrosc. Radiat. Transfer 98, 220-237 (2006). [CrossRef]
  24. K. Katika and L. Pilon, "Steady-state directional diffuse reflectance and fluorescence of human skin," Appl. Opt. 45, 4174-4183 (2006). [CrossRef] [PubMed]
  25. J. Enderlein and R. Erdmann, "Fast fitting of multi-exponential decay curves," Opt. Commun. 134, 371-378 (1997). [CrossRef]
  26. "Fluofit--a MATLAB package for fitting multiexponential fluorescence decay curves," http://www.fz-juelich.de/ibi/ibi-1/enderlein/joerg/fluo/fluo.html, last accessed 22 December 2005.
  27. A. Huntley and R. Drugge, "Anatomy of the skin, the electronic textbook of dermatology," http://www.telemedicine.org/stamford.htm, last accessed 5 February 2007.
  28. I. V. Meglinski and S. J. Matcher, "Monte Carlo method in optical diagnostics of skin and skin tissues," Proc. SPIE 4241, 78-87 (2001). [CrossRef]
  29. A. Krishnaswamy and G. V. G. Baranoski, A Study on Skin Optics, Technical Report CS-2004-01 (School of Computer Science, University of Waterloo, 2004).
  30. V. Tuchin, ed., Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis (SPIE, 2000).
  31. M. F. Modest, Radiative Heat Transfer (Academic, 2002).
  32. H. Quan and Z. Guo, "Fast 3-D optical imaging with transient fluorescence signals," Opt. Express 12, 449-457 (2004). [CrossRef] [PubMed]
  33. D. Y. Churmakov, I. V. Meglinski, S. A. Piletsky, and D. A. Greenhalgh, "Skin fluorescence model based on the Monte Carlo technique," Proc. SPIE 5068, 326-333 (2003). [CrossRef]
  34. J. Q. Lu, X.-H. Hu, and K. Dong, "Modeling of the rough-interface effect on a converging light beam propagating in a skin tissue phantom," Appl. Opt. 39, 5890-5897 (2000). [CrossRef]
  35. K. König and I. Riemann, "High-resolution multiphoton tomography of human skin with subcellular spatial resolution and picosecond time resolution," J. Biomed. Opt. 8, 432-439 (2003). [CrossRef] [PubMed]
  36. J. D. Pitts and M.-A. Mycek, "Design and development of a rapid acquisition laser-based fluorometer with simultaneous spectral and temporal resolution," Rev. Sci. Instrum. 72, 3061-3072 (2001). [CrossRef]
  37. G. L. Cote, M. D. Fox, and R. B. Northrop, "Noninvasive optical polarimetric glucose sensing using a true phase measurement technique," IEEE Trans. Biomed. Eng. 39, 752-756 (1992). [CrossRef] [PubMed]
  38. G. W. Hopkins and G. R. Mauze, "In-vivo NIR diffuse-reflectance tissue spectroscopy of human subjects," Proc. SPIE 3597, 632-641 (1999). [CrossRef]
  39. C.-Y. Wu, "Propagation of scattered radiation in a participating planar medium with pulse irradiation," J. Quant. Spectrosc. Radiat. Transfer 64, 537-548 (2000). [CrossRef]
  40. D. Baillis, L. Pilon, H. Randrianalisoa, R. Gomez, and R. Viskanta, "Measurements of radiation characteristics of fused quartz containing bubbles," J. Opt. Soc. Am. A 21, 149-159 (2004). [CrossRef]
  41. J. Enderlein, "Comments on Fluofit and fitting fluorescence decay curves," Institute of Analytical Chemistry, Chemo- und Biosensors, University of Regensburg, PF 10 10 42, D-93040 Regensburg, Germany (personal communication, 2006).
  42. K. M. Katika, L. Pilon, K. Dipple, S. Levin, J. Blackwell, and H. Berberoglu, "In vivo time-resolved autofluorescence measurements on human skin," Proc. SPIE 6078, 60780L (2006). [CrossRef]
  43. A. Hielscher, S. Jacques, L. Wang, and F. Tittel, "The influence of boundary conditions on the accuracy of diffusion theory in time-resolved reflectance spectroscopy of biological tissues," Phys. Med. Biol. 40, 1957-1975 (1995). [CrossRef] [PubMed]
  44. D. Y. Churmakov, I. V. Meglinski, and D. A. Greenhalgh, "Amending of fluorescence sensor signal localization in human skin by matching of the refractive index," J. Biomed. Opt. 9, 339-346 (2004). [CrossRef] [PubMed]
  45. A. Huntley and R. Drugge, "Diabetes in skin disease. The electronic textbook of dermatology," http://www.telemedicine.org/dm/dmupdate.htm, last accessed 5 February 2007.
  46. E. Hull, M. Ediger, A. Unione, E. Deemer, M. Stroman, and J. Baynes, "Noninvasive, optical detection of diabetes: model studies with porcine skin," Opt. Express 12, 4496-4510 (2004). [CrossRef] [PubMed]
  47. R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, G. Valentini, and E. Sorbellini, "Fluorescence lifetime imaging: an application to the detection of skin tumors," IEEE J. Sel. Top. Quantum Electron. 5, 122-132 (1999).

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