Optical tomography is being developed as a means of detecting and specifying disease in the adult female breast. We present a series of clinical three-dimensional optical images obtained with a 32-channel time-resolved system and a liquid-coupled interface. Patients place their breasts in a hemispherical cup to which sources and detectors are coupled, and the remaining space is filled with a highly scattering fluid. A cohort of 38 patients has been scanned, with a variety of benign and malignant lesions. Images show that hypervascularization associated with tumors provides very high contrast due to increased absorption by hemoglobin. Only half of the fibroadenomas scanned could be observed, but of those that could be detected, all but one revealed an apparent increase in blood volume and a decrease in scatter and oxygen saturation.
© 2007 Optical Society of America
Original Manuscript: October 30, 2006
Revised Manuscript: January 24, 2007
Manuscript Accepted: January 31, 2007
Published: May 18, 2007
Vol. 2, Iss. 7 Virtual Journal for Biomedical Optics
Louise C. Enfield, Adam P. Gibson, Nicholas L. Everdell, David T. Delpy, Martin Schweiger, Simon R. Arridge, Caroline Richardson, Mohammad Keshtgar, Michael Douek, and Jeremy C. Hebden, "Three-dimensional time-resolved optical mammography of the uncompressed breast," Appl. Opt. 46, 3628-3638 (2007)