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Applied Optics

Applied Optics


  • Editor: James C. Wyant
  • Vol. 46, Iss. 20 — Jul. 10, 2007
  • pp: 4486–4490

Multichannel biosensing platform of surface-immobilized gold nanospheres for linear and nonlinear optical imaging

Kazuma Tsuboi, Shinya Fukuba, Ryo Naraoka, Katsuhiko Fujita, and Kotaro Kajikawa  »View Author Affiliations

Applied Optics, Vol. 46, Issue 20, pp. 4486-4490 (2007)

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What we believe to be a new label-free multichannel biosensing platform is proposed. It is composed of surface-immobilized gold nanospheres (SIGNs) above a gold surface with a nanogap supported by a merocyanine self-assembled monolayer. The circular SIGN spots with a diameter of 120 μ m were arrayed for multichannel biosensing on a glass slide. Two kinds of sensing methods were examined: One is a reflectivity measurement of a blue ray and the other is a second-harmonic generation measurement. It was found that the SIGN system can be used as a promising platform for multichannel biosensing in both sensing methods.

© 2007 Optical Society of America

OCIS Codes
(110.2970) Imaging systems : Image detection systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(190.4350) Nonlinear optics : Nonlinear optics at surfaces
(240.4350) Optics at surfaces : Nonlinear optics at surfaces
(240.6680) Optics at surfaces : Surface plasmons

ToC Category:
Imaging Systems

Original Manuscript: January 23, 2007
Revised Manuscript: March 19, 2007
Manuscript Accepted: April 4, 2007
Published: June 20, 2007

Virtual Issues
Vol. 2, Iss. 8 Virtual Journal for Biomedical Optics

Kazuma Tsuboi, Shinya Fukuba, Ryo Naraoka, Katsuhiko Fujita, and Kotaro Kajikawa, "Multichannel biosensing platform of surface-immobilized gold nanospheres for linear and nonlinear optical imaging," Appl. Opt. 46, 4486-4490 (2007)

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