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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 22 — Aug. 1, 2007
  • pp: 4896–4906

Noncontact fluorescence diffuse optical tomography of heterogeneous media

L. Hervé, A. Koenig, A. Da Silva, M. Berger, J. Boutet, J. M. Dinten, P. Peltié, and P. Rizo  »View Author Affiliations


Applied Optics, Vol. 46, Issue 22, pp. 4896-4906 (2007)
http://dx.doi.org/10.1364/AO.46.004896


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Abstract

Fluorescence-enhanced diffuse optical tomography is expected to be useful to the collection of functional information from small animal models. This technique is currently limited by the extent of tissue heterogeneity and management of the shape of the animals. We propose an approach based on the reconstruction of object heterogeneity, which provides an original solution to the two problems. Three evaluation campaigns are described: the first two were performed on phantoms designed to test the reconstructions in highly heterogeneous media and noncontact geometries; the third was conducted on mice with lung tumors to test fluorescence yield reconstruction feasibility in vivo.

© 2007 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(260.2510) Physical optics : Fluorescence

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 20, 2006
Revised Manuscript: March 8, 2007
Manuscript Accepted: April 3, 2007
Published: July 3, 2007

Virtual Issues
Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Citation
L. Hervé, A. Koenig, A. Da Silva, M. Berger, J. Boutet, J. M. Dinten, P. Peltié, and P. Rizo, "Noncontact fluorescence diffuse optical tomography of heterogeneous media," Appl. Opt. 46, 4896-4906 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-22-4896

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