OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 23 — Aug. 10, 2007
  • pp: 5844–5852

Detection of trace Al in model biological tissue with laser-induced breakdown spectroscopy

Marian D. Adamson and Steven J. Rehse  »View Author Affiliations


Applied Optics, Vol. 46, Issue 23, pp. 5844-5852 (2007)
http://dx.doi.org/10.1364/AO.46.005844


View Full Text Article

Enhanced HTML    Acrobat PDF (767 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Laser-induced breakdown spectroscopy (LIBS), which is an excellent tool for trace elemental analysis, was studied as a method of detecting sub-part-per- 10 6 (ppm) concentrations of aluminum in surrogates of human tissue. Tissue was modeled using a 2% agarose gelatin doped with an Al 2 O 3 nanoparticle suspension. A calibration curve created with standard reference samples of known Al concentrations was used to determine the limit of detection, which was less than 1 ppm. Rates of false negative and false positive detection results for a much more realistic sampling methodology were also studied, suggesting that LIBS could be a candidate for the real-time in vivo detection of metal contamination in human soft tissue.

© 2007 Optical Society of America

OCIS Codes
(120.1880) Instrumentation, measurement, and metrology : Detection
(140.3440) Lasers and laser optics : Laser-induced breakdown
(170.1020) Medical optics and biotechnology : Ablation of tissue
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6210) Spectroscopy : Spectroscopy, atomic
(300.6360) Spectroscopy : Spectroscopy, laser

ToC Category:
Spectroscopy

History
Original Manuscript: January 12, 2007
Revised Manuscript: March 30, 2007
Manuscript Accepted: May 29, 2007
Published: August 9, 2007

Virtual Issues
Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Marian D. Adamson and Steven J. Rehse, "Detection of trace Al in model biological tissue with laser-induced breakdown spectroscopy," Appl. Opt. 46, 5844-5852 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-23-5844

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited