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Applied Optics

Applied Optics


  • Editor: James C. Wyant
  • Vol. 46, Iss. 23 — Aug. 10, 2007
  • pp: 5844–5852

Detection of trace Al in model biological tissue with laser-induced breakdown spectroscopy

Marian D. Adamson and Steven J. Rehse  »View Author Affiliations

Applied Optics, Vol. 46, Issue 23, pp. 5844-5852 (2007)

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Laser-induced breakdown spectroscopy (LIBS), which is an excellent tool for trace elemental analysis, was studied as a method of detecting sub-part-per- 10 6 (ppm) concentrations of aluminum in surrogates of human tissue. Tissue was modeled using a 2% agarose gelatin doped with an Al 2 O 3 nanoparticle suspension. A calibration curve created with standard reference samples of known Al concentrations was used to determine the limit of detection, which was less than 1 ppm. Rates of false negative and false positive detection results for a much more realistic sampling methodology were also studied, suggesting that LIBS could be a candidate for the real-time in vivo detection of metal contamination in human soft tissue.

© 2007 Optical Society of America

OCIS Codes
(120.1880) Instrumentation, measurement, and metrology : Detection
(140.3440) Lasers and laser optics : Laser-induced breakdown
(170.1020) Medical optics and biotechnology : Ablation of tissue
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6210) Spectroscopy : Spectroscopy, atomic
(300.6360) Spectroscopy : Spectroscopy, laser

ToC Category:

Original Manuscript: January 12, 2007
Revised Manuscript: March 30, 2007
Manuscript Accepted: May 29, 2007
Published: August 9, 2007

Virtual Issues
Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Marian D. Adamson and Steven J. Rehse, "Detection of trace Al in model biological tissue with laser-induced breakdown spectroscopy," Appl. Opt. 46, 5844-5852 (2007)

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